Document Detail


Associations of n-6 and n-3 polyunsaturated fatty acids and tocopherols with proxies of membrane stability and subcutaneous fat sites in male elite swimmers.
MedLine Citation:
PMID:  19854377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesize that membrane stability of elite swimmers adapted to chronic intense training is dependent on polyunsaturated fatty acids (PUFAs) and tocopherols in blood pools and that the composition of PUFA in plasma nonesterified fatty acids (NEFAs) might be associated with specific subcutaneous fat sites. Our aims were to investigate in male elite swimmers the associations of n-6 and n-3 PUFA and alpha- and gamma-tocopherols with proxies of membrane stability (phase angle and erythrocyte osmotic fragility) and of PUFA in plasma NEFA with specific skinfolds. Brazilian male elite swimmers (n = 20) under regular training for an average of 4.1 h/d and 6.1 d/wk took part in the study. Blood samples were obtained once after 18-hour rest and an overnight fast. Fatty acids were determined in plasma NEFA and erythrocytes by gas chromatolography and tocopherols were determined in plasma and erythrocytes by high-performance liquid chromatography. The status of PUFA was assessed as mean melting point, PUFA index [(Sigman-6 + Sigman-3) / (Sigman-7 + Sigman-9)] and docosahexaenoic acid indices (22:5n-6/22:4n-6 and 22:6n-3/22:5n-6 ratios) calculated from erythrocyte fatty acids. Phase angle was associated with an index of docosahexaenoic acid inadequacy (22:5n-6/22:4n-6; r = -0.53, P = .019) and with 22:5n-3 in erythrocytes (r = 0.51, P = .024), and erythrocyte osmotic fragility was associated with plasma alpha-tocopherol (r = -0.51, P = .05), which is a biomarker of vitamin E status. Plasma NEFAs 18:3n-3 and 20:4n-6 were positively associated with skinfolds of the trunk and arms (r = 0.49-0.59, P = .011-.043). The data presented indicate that n-3 PUFA and vitamin E states possibly improve membrane stability in elite swimmers and that the extent of specific anatomic sites of subcutaneous adipose tissue in the upper body might contribute to the composition of NEFA in the resting state.
Authors:
Jacqueline G Ney; Josely C Koury; Vilma B Azeredo; Gustavo Casimiro-Lopes; Nadia M F Trugo; Alexandre G Torres
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  29     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-30     Citation Subset:  IM    
Affiliation:
Laboratorio de Bioquimica Nutricional e de Alimentos, Departamento de Bioquimica, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Athletes
Cross-Sectional Studies
Electric Impedance
Erythrocyte Membrane / metabolism*
Exercise / physiology*
Fatty Acids / blood*
Fatty Acids, Nonesterified / blood,  chemistry
Fatty Acids, Omega-6 / blood
Humans
Male
Osmosis
Physical Exertion / physiology*
Skinfold Thickness
Subcutaneous Fat* / metabolism
Swimming / physiology*
Vitamin E / blood*
Young Adult
alpha-Tocopherol / blood
gamma-Tocopherol / blood
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-6; 0/gamma-Tocopherol; 1406-18-4/Vitamin E; 59-02-9/alpha-Tocopherol

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