Document Detail

Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis.
MedLine Citation:
PMID:  22261546     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the associations of alcohol consumption patterns with disability and brain injury in multiple sclerosis (MS) patients.
DESIGN: This study included 423 subjects (272 MS patients, 151 healthy controls) participating in a study of clinical, environmental and genetic risk factors in MS. Disability was assessed with the Expanded Disability Status Scale (EDSS) and the MS Severity Scale (MSSS). Brain injury was assessed using the quantitative MRI measures of T2-lesion volume (T2-LV), T1-LV, normalized volumes of brain parenchyma (NBV), gray matter (NGMV) and lateral ventricle (NLVV). Information related to alcohol-consumption patterns was obtained with standardized questionnaire during an in-person interview. The associations of alcohol consumption variables with disability and MRI measures were assessed in regression analyses.
RESULTS: The frequency of MS patients who did not consume alcohol after MS (19.4%) was higher than the frequency before MS (p<0.001). The EDSS, NGMV and NLVV exhibited a non-linear dependence on duration of alcohol consumption after MS onset: non-linear regression analyses indicated that EDSS and NLVV were lower and the NGMV was greater in MS patients who had consumed for a period of 15years or less after MS onset compared those who did not consume alcohol or consumed it for more than 15years.
CONCLUSION: The duration of alcohol consumption is associated with disability and MRI measures in MS. Prospective, longitudinal studies of the role of alcohol in MS disease progression are warranted.
Mathew Foster; Robert Zivadinov; Bianca Weinstock-Guttman; Miriam Tamaño-Blanco; Darlene Badgett; Ellen Carl; Murali Ramanathan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-01-18
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  243     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-04-05     Revised Date:  2012-07-24    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA.
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MeSH Terms
Alcohol Drinking / epidemiology*
Brain / pathology*
Disability Evaluation
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Middle Aged
Multiple Sclerosis / epidemiology*,  pathology*
Regression Analysis
Severity of Illness Index
Grant Support
MS090122//PHS HHS
Comment In:
Expert Rev Neurother. 2012 Jun;12(6):657-60   [PMID:  22650167 ]

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