Document Detail

Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort.
MedLine Citation:
PMID:  24500149     Owner:  NLM     Status:  Publisher    
BACKGROUND: Inflammation plays an important role in endometrial cancer etiology. Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs), derived from marine sources, are thought to be antiinflammatory; however, several studies of fish consumption suggest an increase in risk.
OBJECTIVE: This study examined whether intakes of long-chain ω-3 PUFAs, including eicosapentaenoic acid (EPA; 20:5ω-3) and docosahexaenoic acid (DHA; 22:6ω-3), from diet and supplements and intake of fish are associated with endometrial cancer risk.
DESIGN: Between 2000 and 2002, 22,494 women aged 50-76 y, living in western Washington State, were recruited to the VITamins And Lifestyle cohort study. Incident endometrial cancers (n = 263) were identified through the Surveillance, Epidemiology, and End Results cancer registry after 9 y of follow-up. Multivariable-adjusted HRs and 95% CIs for the association of intakes of individual long-chain ω-3 PUFAs and fish with endometrial cancer risk were estimated by using Cox proportional hazards.
RESULTS: Women in the highest compared with the lowest quintile of dietary EPA + DHA intake had a 79% increased risk of endometrial cancer (95% CI: 16%, 175%; P-trend = 0.026). Results were similar for EPA and DHA measured individually and for fish intake. When data were stratified by body mass index (in kg/m(2); <25 or ≥25), increases in risk of long-chain ω-3 PUFAs were restricted to overweight and obese women, and statistically significant reductions in risk were observed for normal-weight women.
CONCLUSIONS: The overall increased risk reported here confirms the findings of several prior observational studies of fish intake, which observed similar increases in risk. Randomized trials are needed to confirm these findings.
Theodore M Brasky; Marian L Neuhouser; David E Cohn; Emily White
Related Documents :
23733549 - Racial and ethnic differences in hospice enrollment among children with cancer.
24625429 - What should we tell prostate cancer patients about (secondary) prevention?
23663559 - Outcome of 12 month surveillance colonoscopy in high risk patients in the nhs bowel can...
23543319 - Priorities of head and neck cancer patients: a patient survey based on the brief icf co...
24074129 - Social epidemiology: a tool for examining prostate cancer early-detection decision maki...
25078599 - Functional polymorphisms in micrornas and susceptibility to liver cancer: a meta-analys...
19405709 - Extracting diagnostic stromal organization features based on intrinsic two-photon excit...
3731139 - Combination chemotherapy with mitomycin and vindesine in advanced non-small cell lung c...
24766319 - Targeting inflammation in cancer-related-fatigue: a rationale for mistletoe therapy as ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-5
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  -     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects and blood concentrations of cobalt after ingestion of 1 mg/d by human volunteers for 90 d.
Next Document:  Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein ...