| Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. | |
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MedLine Citation:
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PMID: 22222417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS AND RESULTS: Total and visceral adiposity and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of 4 towns in Sardinia, Italy. Arterial stiffness was measured as aortic pulse wave velocity (PWV), arterial thickness and lumen as common carotid artery (CCA) intima-media thickness (IMT) and diameter, respectively. We reported a nonlinear relationship between total and visceral adiposity and arterial stiffness, thickness, and diameter. The association between adiposity and arterial properties was steeper in women than in men, in younger than in older subjects. Waist correlated with arterial properties better than BMI. Within each BMI quartile, increasing waist circumference was associated with further significant changes in arterial structure and function. CONCLUSION: The relationship between total or abdominal adiposity and arterial aging (PWV and CCA IMT) is not linear as described in the current study. Therefore, BMI- and/or waist-specific reference values for arterial measurements might need to be defined. |
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Authors:
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Angelo Scuteri; Marco Orru'; Christopher H Morrell; Kirill Tarasov; David Schlessinger; Manuela Uda; Edward G Lakatta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2011-12-14 |
Journal Detail:
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Title: Atherosclerosis Volume: 221 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-06-12 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 189-97 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ireland Ltd. |
Affiliation:
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Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, USA. angeloelefante@interfree.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Adolescent Adult Age Factors Aged Aged, 80 and over Aging* Body Mass Index Carotid Artery, Common* / physiopathology, ultrasonography Carotid Intima-Media Thickness Female Femoral Artery* / physiopathology, ultrasonography Humans Hypertension / epidemiology*, physiopathology, ultrasonography Italy / epidemiology Linear Models Male Middle Aged Multivariate Analysis Nonlinear Dynamics Obesity, Abdominal / epidemiology*, physiopathology, ultrasonography Pulsatile Flow Risk Assessment Risk Factors Sex Factors Vascular Diseases / epidemiology*, physiopathology, ultrasonography Waist Circumference Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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N01-AG-1-2109/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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