Document Detail

Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study.
MedLine Citation:
PMID:  22222417     Owner:  NLM     Status:  MEDLINE    
METHODS AND RESULTS: Total and visceral adiposity and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of 4 towns in Sardinia, Italy. Arterial stiffness was measured as aortic pulse wave velocity (PWV), arterial thickness and lumen as common carotid artery (CCA) intima-media thickness (IMT) and diameter, respectively. We reported a nonlinear relationship between total and visceral adiposity and arterial stiffness, thickness, and diameter. The association between adiposity and arterial properties was steeper in women than in men, in younger than in older subjects. Waist correlated with arterial properties better than BMI. Within each BMI quartile, increasing waist circumference was associated with further significant changes in arterial structure and function.
CONCLUSION: The relationship between total or abdominal adiposity and arterial aging (PWV and CCA IMT) is not linear as described in the current study. Therefore, BMI- and/or waist-specific reference values for arterial measurements might need to be defined.
Angelo Scuteri; Marco Orru'; Christopher H Morrell; Kirill Tarasov; David Schlessinger; Manuela Uda; Edward G Lakatta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-12-14
Journal Detail:
Title:  Atherosclerosis     Volume:  221     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-12     Revised Date:  2013-07-21    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ireland Ltd.
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Body Mass Index
Carotid Artery, Common* / physiopathology,  ultrasonography
Carotid Intima-Media Thickness
Femoral Artery* / physiopathology,  ultrasonography
Hypertension / epidemiology*,  physiopathology,  ultrasonography
Italy / epidemiology
Linear Models
Middle Aged
Multivariate Analysis
Nonlinear Dynamics
Obesity, Abdominal / epidemiology*,  physiopathology,  ultrasonography
Pulsatile Flow
Risk Assessment
Risk Factors
Sex Factors
Vascular Diseases / epidemiology*,  physiopathology,  ultrasonography
Waist Circumference
Young Adult
Grant Support
N01-AG-1-2109/AG/NIA NIH HHS; ZIA AG000675-04/AG/NIA NIH HHS

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