Document Detail


Associations of the lactase persistence allele and lactose intake with body composition among multiethnic children.
MedLine Citation:
PMID:  23479116     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Childhood obesity is a worldwide health concern with a multifaceted and sometimes confounding etiology. Dairy products have been implicated as both pro- and anti-obesogenic, perhaps due to the confounding relationship between dairy, lactose consumption, and potential genetic predisposition. We aimed to understand how lactase persistence influenced obesity-related traits by observing the relationships among lactose consumption, a single nucleotide polymorphism (SNP) near the lactase (LCT) gene and body composition parameters in a sample of multiethnic children (n = 296, 7-12 years old). We hypothesized that individuals with the lactase persistence (LP) allele of the LCT SNP (rs4988235) would exhibit a greater degree of adiposity and that this relationship would be mediated by lactose consumption. Body composition variables were measured using dual X-ray absorptiometry and a registered dietitian assessed dietary intake of lactose. Statistical models were adjusted for sex, age, pubertal stage, ethnic group, genetic admixture, socio-economic status, and total energy intake. Our findings indicate a positive, significant association between the LP allele and body mass index (p = 0.034), fat mass index (FMI) (p = 0.043), and waist circumference (p = 0.008), with associations being stronger in males than in females. Our results also reveal that lactose consumption is positively and nearly significantly associated with FMI.
Authors:
Adil J Malek; Yann C Klimentidis; Kenneth P Kell; José R Fernández
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Publication Detail:
Type:  Journal Article     Date:  2013-03-12
Journal Detail:
Title:  Genes & nutrition     Volume:  8     ISSN:  1555-8932     ISO Abbreviation:  Genes Nutr     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-28     Completed Date:  2013-08-28     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  101280108     Medline TA:  Genes Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  487-94     Citation Subset:  -    
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Grant Support
ID/Acronym/Agency:
P30 DK056336/DK/NIDDK NIH HHS; P30 DK079626/DK/NIDDK NIH HHS; P60 DK079626/DK/NIDDK NIH HHS; R01 DA025095/DA/NIDA NIH HHS; T32 HL007457/HL/NHLBI NIH HHS; T32 HL105349/HL/NHLBI NIH HHS

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