Document Detail

Associations of fibrinogen and C-reactive protein with prevalent and incident coronary heart disease are attenuated by adjustment for confounding factors. British Women's Heart and Health Study.
MedLine Citation:
PMID:  15886815     Owner:  NLM     Status:  MEDLINE    
A cross sectional and prospective analysis of 3,745 British women aged 60-79 years at baseline was undertaken. Among these women there were 570 prevalent cases of coronary heart disease (CHD) and 151 new cases among 12,641 person-years of follow up of women who were free of CHD at baseline. Both fibrinogen and CRP were associated with indicators of socioeconomic position in childhood and adulthood and there was a cumulative effect of socioeconomic position from across the life course. The age-adjusted odds ratio (95% confidence interval) of prevalent CHD for a 1 unit (1 g/L) increase in fibrinogen was 1.29 (1.12, 1.49); with full adjustment for all potential confounding factors this attenuated to 1.09 (0.93, 1.28). The hazards ratio for incident CHD among those free of disease at baseline was 1.28 (1.00, 1.64); with full adjustment for all potential confounding factors this attenuated to 1.09 (0.84, 1.44). Similar effects of adjustment for confounding factors were seen for the associations between CRP and both prevalent and incident CHD. By contrast, the strong positive association between smoking (an established causal risk factor for CHD) and CHD was not attenuated by adjustment for life course socioeconomic position or other risk factors. We conclude that fibrinogen and CRP predict CHD but may not be causally related to it.
Debbie A Lawlor; George Davey Smith; Ann Rumley; Gordon D O Lowe; Shah Ebrahim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  93     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-08-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  955-63     Citation Subset:  IM    
Department of Social Medicine, University of Bristol, UK.
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MeSH Terms
Age Factors
Arteriosclerosis / blood*,  epidemiology*
C-Reactive Protein / biosynthesis,  physiology*
Confounding Factors (Epidemiology)
Coronary Artery Disease / blood,  epidemiology
Coronary Disease / blood*,  epidemiology*
Fibrin / genetics
Fibrinogen / biosynthesis,  physiology*
Middle Aged
Models, Statistical
Odds Ratio
Prospective Studies
Risk Factors
Social Class
Reg. No./Substance:
9001-31-4/Fibrin; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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