| Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese. | |
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MedLine Citation:
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PMID: 23015321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial. OBJECTIVE: We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population. DESIGN: Erythrocyte fatty acids were measured in a population-based sample of 3107 men and women aged 50-70 y, for whom plasma glucose, insulin, lipid profile, adiponectin, retinol binding protein 4 (RBP-4), plasminogen activator inhibitor type 1, and high-sensitivity C-reactive protein (hsCRP) were measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. RESULTS: The mean (±SD) erythrocyte palmitoleic acid value was 0.41 ± 0.20% of total fatty acids. Palmitoleic acid was positively correlated with RBP-4 (r = 0.14, P < 0.001) and inversely correlated with adiponectin (r = -0.15, P < 0.001). After multivariable adjustment, palmitoleic acid was strongly associated with MetS and its components. ORs (95% CIs) for comparisons of extreme quartiles of palmitoleic acid were 3.50 (2.66, 4.59) for MetS, 7.88 (5.90, 10.52) for hypertriglyceridemia, 2.13 (1.66, 2.72) for reduced HDL cholesterol, 1.99 (1.60, 2.48) for central obesity, and 1.86 (1.41, 2.44) for elevated blood pressure (all P < 0.001). Further control for adipokines and hsCRP abolished the association of palmitoleic acid with central obesity but not with other MetS components. CONCLUSION: Erythrocyte palmitoleic acid is associated with an adverse profile of adipokines and inflammatory markers and an increased risk of MetS in this Chinese population. |
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Authors:
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Geng Zong; Xingwang Ye; Liang Sun; Huaixing Li; Zhijie Yu; Frank B Hu; Qi Sun; Xu Lin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-09-26 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 96 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-22 Completed Date: 2013-03-18 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 970-6 Citation Subset: AIM; IM |
Affiliation:
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Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Age Factors Aged Asian Continental Ancestry Group Blood Glucose / analysis, metabolism Blood Pressure C-Reactive Protein / metabolism Cholesterol / blood Erythrocytes / metabolism* Fatty Acids, Monounsaturated / analysis* Female Humans Inflammation Mediators / blood* Insulin / blood Lipids / blood Logistic Models Male Metabolic Syndrome X / blood* Middle Aged Multivariate Analysis Plasminogen Activator Inhibitor 1 / blood Retinol-Binding Proteins, Plasma / metabolism Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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K99HL098459/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Blood Glucose; 0/Fatty Acids, Monounsaturated; 0/Inflammation Mediators; 0/Insulin; 0/Lipids; 0/Plasminogen Activator Inhibitor 1; 0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma; 0/Triglycerides; 209B6YPZ4I/palmitoleic acid; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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