|Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese.|
|PMID: 23015321 Owner: NLM Status: MEDLINE|
|BACKGROUND: Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial.
OBJECTIVE: We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population.
DESIGN: Erythrocyte fatty acids were measured in a population-based sample of 3107 men and women aged 50-70 y, for whom plasma glucose, insulin, lipid profile, adiponectin, retinol binding protein 4 (RBP-4), plasminogen activator inhibitor type 1, and high-sensitivity C-reactive protein (hsCRP) were measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.
RESULTS: The mean (±SD) erythrocyte palmitoleic acid value was 0.41 ± 0.20% of total fatty acids. Palmitoleic acid was positively correlated with RBP-4 (r = 0.14, P < 0.001) and inversely correlated with adiponectin (r = -0.15, P < 0.001). After multivariable adjustment, palmitoleic acid was strongly associated with MetS and its components. ORs (95% CIs) for comparisons of extreme quartiles of palmitoleic acid were 3.50 (2.66, 4.59) for MetS, 7.88 (5.90, 10.52) for hypertriglyceridemia, 2.13 (1.66, 2.72) for reduced HDL cholesterol, 1.99 (1.60, 2.48) for central obesity, and 1.86 (1.41, 2.44) for elevated blood pressure (all P < 0.001). Further control for adipokines and hsCRP abolished the association of palmitoleic acid with central obesity but not with other MetS components.
CONCLUSION: Erythrocyte palmitoleic acid is associated with an adverse profile of adipokines and inflammatory markers and an increased risk of MetS in this Chinese population.
|Geng Zong; Xingwang Ye; Liang Sun; Huaixing Li; Zhijie Yu; Frank B Hu; Qi Sun; Xu Lin|
|Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-09-26|
|Title: The American journal of clinical nutrition Volume: 96 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Nov|
|Created Date: 2012-10-22 Completed Date: 2013-03-18 Revised Date: 2014-03-19|
Medline Journal Info:
|Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States|
|Languages: eng Pagination: 970-6 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Asian Continental Ancestry Group
Blood Glucose / analysis, metabolism
C-Reactive Protein / metabolism
Cholesterol / blood
Erythrocytes / metabolism*
Fatty Acids, Monounsaturated / analysis*
Inflammation Mediators / blood*
Insulin / blood
Lipids / blood
Metabolic Syndrome X / blood*
Plasminogen Activator Inhibitor 1 / blood
Retinol-Binding Proteins, Plasma / metabolism
Triglycerides / blood
|K99 HL098459/HL/NHLBI NIH HHS; K99HL098459/HL/NHLBI NIH HHS; R00 HL098459/HL/NHLBI NIH HHS|
|0/Adiponectin; 0/Blood Glucose; 0/Fatty Acids, Monounsaturated; 0/Inflammation Mediators; 0/Insulin; 0/Lipids; 0/Plasminogen Activator Inhibitor 1; 0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma; 0/Triglycerides; 209B6YPZ4I/palmitoleic acid; 9007-41-4/C-Reactive Protein; 97C5T2UQ7J/Cholesterol|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic a...
Next Document: Vitamin D and the racial difference in the genotype 1 chronic hepatitis C treatment response.