Document Detail


Associations for change in physical and psychological factors and treatment response following exercise in knee osteoarthritis: an exploratory study.
MedLine Citation:
PMID:  22674892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Understanding how changes in physical and psychological factors following therapeutic exercise are associated with treatment outcome could have important implications for refining rehabilitation programs for knee osteoarthritis (OA). The objective of this study was to examine the association of changes in these factors with changes in pain and function after an exercise program for people with knee OA.
METHODS: In total, 152 people with knee OA completed an exercise program consisting of lower extremity strengthening, stretching, range of motion, balance and agility, and aerobic exercises. The change from baseline to the 2-month followup was calculated for physical and psychological factors, including self-reported knee instability, quadriceps strength, knee and ankle range of motion, lower extremity muscle flexibility, fear of physical activity, anxiety, and depressive symptoms. Treatment response was defined as a minimum of a 20% improvement from baseline in both a numerical knee pain rating scale and the Western Ontario and McMaster Universities Osteoarthritis Index physical function scale. The association of each factor with treatment response was examined with logistic regression mutually adjusted for age, sex, body mass index, radiographic severity, and exercise group.
RESULTS: Change in self-reported knee instability (odds ratio [OR] 1.67 [95% confidence interval (95% CI) 1.13-2.47]) and fear of physical activity (OR 0.93 [95% CI 0.88-1.00]) were the only 2 factors that were significantly associated with treatment response after adjustment for covariates.
CONCLUSION: Improvement in knee instability and fear of physical activity were associated with increased odds of a positive treatment response following therapeutic exercise in subjects with knee OA.
Authors:
G Kelley Fitzgerald; Daniel K White; Sara R Piva
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Arthritis care & research     Volume:  64     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-31     Completed Date:  2013-01-07     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1673-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
University of Pittsburgh, Pennsylvania, USA. kfitzger@pitt.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00078624
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MeSH Terms
Descriptor/Qualifier:
Aged
Anxiety / epidemiology,  psychology
Depression / epidemiology,  psychology
Exercise Therapy / methods*,  psychology*
Female
Follow-Up Studies
Humans
Joint Instability / epidemiology,  psychology,  therapy
Knee Joint / physiopathology
Male
Middle Aged
Muscle, Skeletal / physiology
Osteoarthritis, Knee / epidemiology,  psychology*,  therapy*
Pilot Projects
Treatment Outcome
Grant Support
ID/Acronym/Agency:
1-R01-AR048760/AR/NIAMS NIH HHS; P30 AG024827/AG/NIA NIH HHS; R01 AR048760/AR/NIAMS NIH HHS
Comments/Corrections

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