| Associations of catalase gene polymorphisms with bone mineral density and bone turnover markers in postmenopausal women. | |
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MedLine Citation:
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PMID: 17209132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oxidative stress has been recently suggested to play a part in the development of osteoporosis. Catalase is a major antioxidant enzyme that detoxifies hydrogen peroxide by converting it into water and oxygen, thereby preventing cellular injury by oxidative stress. AIMS: To examine the associations between the catalase gene (CAT) polymorphisms and bone mineral density (BMD) and bone turnover markers in postmenopausal Korean women. METHODS: All exons, their boundaries and the promoter region (approximately 1.5 kb) were directly sequenced in 24 individuals. Among 18 variants identified by a direct sequence method, four polymorphisms were selected and genotyped in all study participants (n = 560). BMD at the lumbar spine and proximal femur was measured using dual-energy x ray absorptiometry. Serum osteocalcin concentrations and bone-specific alkaline phosphatase activity were determined by an immunoradiometric assay and an immunoassay, respectively. RESULTS: The mean (standard deviation) age of the participants was 59.4 (7.2) years. Multivariate analysis showed an association of the +22348C-->T polymorphism with BMD at the lumbar spine (p = 0.01 in the dominant model) and at femur neck (p = 0.05 in the dominant model), and with serum osteocalcin level (p = 0.008 in the dominant model). Haplotype analyses showed that HT4 (-20T, +144C, +22348T, +33078A) was significantly associated with higher BMD at various sites (p<0.001-0.03) and with lower serum osteocalcin levels (p = 0.01 in the codominant model). CONCLUSIONS: These findings indicate that the +22348C-->T polymorphism and HT4 of CAT may be useful genetic markers for bone metabolism. |
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Authors:
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Bermseok Oh; Shin-Yoon Kim; Duk Jae Kim; Jong Yong Lee; Jong-Keuk Lee; Kuchan Kimm; Byung Lae Park; Hyoung Doo Shin; Tae-Ho Kim; Eui Kyun Park; Jung-Min Koh; Ghi Su Kim |
Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical genetics Volume: 44 ISSN: 1468-6244 ISO Abbreviation: J. Med. Genet. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-08 Completed Date: 2007-01-30 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 2985087R Medline TA: J Med Genet Country: England |
Other Details:
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Languages: eng Pagination: e62 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alkaline Phosphatase / blood Asian Continental Ancestry Group / genetics Bone Density / genetics* Catalase / genetics* Female Genetic Markers Haplotypes Humans Middle Aged Osteocalcin / blood Osteoporosis, Postmenopausal / genetics*, metabolism Oxidative Stress Polymorphism, Single Nucleotide* Spine / pathology |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 104982-03-8/Osteocalcin; EC 1.11.1.6/Catalase; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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