| Associations of cardiorespiratory fitness and parental history of diabetes with risk of type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 22119534 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: We examined the independent and joint associations of cardiorespiratory fitness (CRF) and parental diabetes history on type 2 diabetes risk. METHODS: A cohort of 11,627 individuals aged 20-79years was free of baseline diabetes, cardiovascular disease, and cancer. We measured CRF using a maximal treadmill exercise test, and parental diabetes by a medical history questionnaire. RESULTS: During an average 5.5year follow-up, 572 cases of type 2 diabetes occurred. Compared with the least fit 20%, the multivariate hazard ratio (HR) (95% CI) was 0.59 (0.43-0.83) for the middle fit 40%, and 0.53 (0.38-0.75) for the high fit 40%. Those with parental diabetes had a 1.40-fold higher risk for developing type 2 diabetes. In combined analyses using fit, no parental diabetes as the referent, unfit with no parental diabetes was 1.79 (95% CI 1.25-2.57) times more likely to develop type 2 diabetes, while the risk with parental diabetes was 1.41 (95% CI 1.12-1.78) and 2.37 (95% CI 1.25-4.49) times higher in the fit and unfit, respectively. CONCLUSIONS: While high CRF did not fully attenuate the risk of diabetes associated with parental diabetes, being fit reduces diabetes risk regardless of parental history. |
| | |
Authors:
|
Kara M Goodrich; Shannon K Crowley; Duck-Chul Lee; Xuemei S Sui; Steven P Hooker; Steven N Blair |
Related Documents
:
|
1643804 - Screening programme for microvascular complications and hypertension in a community dia... 15210604 - Relationship between erectile dysfunction and silent myocardial ischemia in apparently ... 7964224 - An evaluation of glycosylated hemoglobin measurement by a colorimetric method as a scre... 15603954 - Benzoyl 2-methyl indoles as selective ppargamma modulators. 22317894 - The branching pattern of villous capillaries and structural changes of placental termin... 21930604 - Paradoxical effects of streptozocin-induced diabetes on endothelium dysfunction in stro... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: - ISSN: 1872-8227 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
University of South Carolina, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coagulation abnormalities in deceased donors are associated with unsuccessful human islet cell isola...
Next Document: PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking.