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Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study.
MedLine Citation:
PMID:  21550607     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Nutritional factors in early life may have long-term physiologic effects in humans. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play important roles in protecting against cardiovascular disease (CVD) risk. Our aim was to examine the association of birth weight (BW) with serum long chain polyunsaturated fatty acids (LCPUFA) profile in adolescents. SUBJECTS AND METHODS: A total of 772 European adolescents (56.3% females) aged 14.7±1.2 years were included in this study. Information on BW and gestational age was obtained from parental records. DHA, EPA and arachidonic acid (AA) concentrations were measured in serum phospholipids. Alfa-linolenic (ALA), linoleic (LA), AA, EPA and DHA intakes assessed by a computer based 24h dietary recall. Gender, gestational age, pubertal status, body mass index, center and total energy and LCPUFA intakes were used as confounders in all the analyses. RESULTS: BW was significantly associated with serum DHA and EPA (both adjusted P<0.05) independently of potential confounders including their main dietetic source. We did not observe any significant relationship between BW and serum AA levels. CONCLUSIONS: Our findings suggest that early metabolic changes, as a result from prenatal environmental influences, could affect long chain polyunsaturated fatty acid metabolism later in life. These results may contribute to explain the relationship between early nutrition and growth and later metabolic disorders as CVD.
Authors:
Idoia Labayen; Luis A Moreno; Jonatan R Ruiz; Francisco B Ortega; Michael Sjostrom; Inge Huybrechts; Marcela Gonzalez-Gross; André Spinneker; Stefaan De Henauw; Yannis Manios; Dénés Molnar; Catherine Leclercq; Frédéric Gottrand;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain; GENUD (Growth, Exercise, Nutrition and Development) Research Group, Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, 50009 Zaragoza, Spain.
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