Document Detail

Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.
MedLine Citation:
PMID:  11199064     Owner:  NLM     Status:  MEDLINE    
Eighty-four healthy graduate participants were administered the standard course of 3 hepatitis B vaccinations. Five months after the first dose (shortly after the second injection), each participant completed psychosocial measures, and a blood sample was drawn for determination of hepatitis B surface antibody titer. After completion of the vaccination series, participants performed an acute stress protocol, consisting of a 30-min adaptation period and a 5-min evaluative speech task. Blood was drawn at the end of the resting and task periods for assessment of cellular immune measures. Lower antibody response, as assessed after the second hepatitis B injection, was predicted independently by (a) high trait negative affect and (b) diminished T-cell proliferation in response to PHA. These data provide evidence that trait negative affect and the magnitude of stress-induced suppression of immune function may have clinical significance.
A L Marsland; S Cohen; B S Rabin; S B Manuck
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Health psychology : official journal of the Division of Health Psychology, American Psychological Association     Volume:  20     ISSN:  0278-6133     ISO Abbreviation:  Health Psychol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211523     Medline TA:  Health Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-11     Citation Subset:  IM    
Behavioral Medicine Program, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213-2593, USA.
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MeSH Terms
Antibody Formation
Cell Division
Hepatitis B / immunology*,  psychology*
Hepatitis B Surface Antigens / analysis
Hepatitis B Vaccines / immunology*
Immunity, Cellular / immunology
Stress, Psychological*
T-Lymphocytes / immunology
Grant Support
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines

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