Document Detail


Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.
MedLine Citation:
PMID:  11199064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eighty-four healthy graduate participants were administered the standard course of 3 hepatitis B vaccinations. Five months after the first dose (shortly after the second injection), each participant completed psychosocial measures, and a blood sample was drawn for determination of hepatitis B surface antibody titer. After completion of the vaccination series, participants performed an acute stress protocol, consisting of a 30-min adaptation period and a 5-min evaluative speech task. Blood was drawn at the end of the resting and task periods for assessment of cellular immune measures. Lower antibody response, as assessed after the second hepatitis B injection, was predicted independently by (a) high trait negative affect and (b) diminished T-cell proliferation in response to PHA. These data provide evidence that trait negative affect and the magnitude of stress-induced suppression of immune function may have clinical significance.
Authors:
A L Marsland; S Cohen; B S Rabin; S B Manuck
Related Documents :
16117704 - Prevention of hepatitis a by havrix: a review.
7875094 - Hepatitis b virus infection among blood donors and pregnant women in maiduguri, nigeria.
7038174 - The newly licensed hepatitis b vaccine. characteristics and indications for use.
9730294 - Immune thrombocytopenic purpura after recombinant hepatitis b vaccine: retrospective st...
25301114 - Comparative genomic analysis of genogroup 1 (wa-like) rotaviruses circulating in the us...
12761124 - Disparity in functional activity between serum anticapsular antibodies induced in adult...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Health psychology : official journal of the Division of Health Psychology, American Psychological Association     Volume:  20     ISSN:  0278-6133     ISO Abbreviation:  Health Psychol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211523     Medline TA:  Health Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-11     Citation Subset:  IM    
Affiliation:
Behavioral Medicine Program, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213-2593, USA. marslandal@msx.upmc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Affect*
Antibody Formation
Cell Division
Female
Hepatitis B / immunology*,  psychology*
Hepatitis B Surface Antigens / analysis
Hepatitis B Vaccines / immunology*
Humans
Immunity, Cellular / immunology
Male
Stress, Psychological*
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
HL40962/HL/NHLBI NIH HHS; MH00721/MH/NIMH NIH HHS; MH50439/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Health locus of control in late life: a study of genetic and environmental influences in twins aged ...
Next Document:  An exploratory study of social support, distress, and life disruption among low-income Hispanic wome...