Document Detail

Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status.
MedLine Citation:
PMID:  12956442     Owner:  NLM     Status:  MEDLINE    
This study investigated the associations between serum transferrin receptor (sTfR) concentrations and erythropoietic activities during 3 stages of iron deficiency in humans. Serum iron markers, fluorescent intensity of reticulocytes, and sTfR concentrations were measured in 227 prepubescent children, age 9 to 12 yr. Reticulocyte subpopulations were analyzed by flow cytometry and sTfR concentrations were measured by enzyme immunoassay. Mean values of middle-fluorescence reticulocytes (MFR), reticulocyte maturity index (RMI), and sTfR concentrations were significantly higher in iron-deficiency anemia subjects than in healthy controls. Reticulocyte subpopulations increased gradually, as body iron status diminished; the mean values of MFR and RMI in subjects with serum ferritin concentrations < 4.0 microg/L were 3-fold higher than those in healthy controls (p < 0.01). Correlation coefficients of MFR and RMI vs log ferritin values (r = 0.43 and r = 0.42) were higher than those of MFR and RMI vs sTfR concentrations (r = 0.24 and r = 0.27) in iron-deficiency anemia subjects. In summary, iron deficiency leads to increased production of immature reticulocytes. Erythropoietic activity is more closely associated with log ferritin values than with sTfR concentrations in iron-deficiency anemia.
Jong Weon Choi; Soo Hwan Pai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  33     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-05     Completed Date:  2004-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea.
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MeSH Terms
Anemia, Iron-Deficiency / blood*
Biological Markers
Erythrocyte Indices
Erythropoiesis / physiology*
Ferritins / metabolism
Flow Cytometry
Iron / metabolism*
Receptors, Transferrin / blood*
Reference Values
Reticulocyte Count
Reticulocytes / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

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