Document Detail

Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet.
MedLine Citation:
PMID:  18951250     Owner:  NLM     Status:  MEDLINE    
Perinatal asphyxia is a significant contributor to neonatal brain injury. However, there is significant variability in neurological outcome in neonates after global hypoxia-ischemia. The aims of this study were to identify which physiological response/s during global hypoxia-ischemia influence the severity of brain injury and to assess their relative importance. Hypoxia/hypercapnia was induced in 20 anaesthetized piglets by reducing the inspired oxygen fraction to 10% and the ventilation rate from 30 to 10 breaths per minute for 45 min. Neurological outcome was assessed using functional markers including cerebral function amplitude (via electroencephalography) and cerebral impedance, and the structural marker microtubule associated protein-2 by immunohistochemistry at 6 h post hypoxia. Significant variability in neurological outcome was observed following the constant hypoxia/hypercapnia insult. There was a high degree of variability in cardiovascular function (mean arterial blood pressure and heart rate) and serum cortisol concentrations in response to hypoxia. More effective maintenance of cardiovascular function and higher serum cortisol concentrations were associated with a better outcome. These two variables were strongly associated with neurological outcome, and together explained 68% of the variation in the severity of neurological outcome. The variability in the cardiovascular and cortisol responses to hypoxia may be a more important determinant of neurological outcome then previously recognized.
Thomas A Harris; Genevieve N Healy; Paul B Colditz; Barbara E Lingwood
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  12     ISSN:  1607-8888     ISO Abbreviation:  Stress     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-01     Revised Date:  2012-03-19    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  294-304     Citation Subset:  IM    
Perinatal Research Centre, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
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MeSH Terms
Animals, Newborn
Blood Pressure
Brain Edema / physiopathology
Cardiovascular Physiological Phenomena
Electric Impedance
Heart Rate
Hydrocortisone / blood*
Hypoxia-Ischemia, Brain / blood,  physiopathology*
Microtubule-Associated Proteins / metabolism
Reg. No./Substance:
0/Microtubule-Associated Proteins; 50-23-7/Hydrocortisone

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