Document Detail

Associations between salivary testosterone and cortisol levels and neonatal health and growth outcomes.
MedLine Citation:
PMID:  22633533     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Male vulnerability in health and growth outcomes has often been reported in very low birth weight (VLBW) preterm neonates. On the basis of gender-difference theories, possible associations were explored between the levels of postnatal salivary testosterone/cortisol and the outcomes of neonatal health/growth.
METHODS: This study used an exploratory and comparative research design. One-hundred-one mother-VLBW preterm neonate pairs were recruited from the neonatal intensive care unit (NICU) of a tertiary medical center in the Southeastern, US. Demographic information, health and growth variables of neonates, and pregnancy and labor variables of mothers were obtained from the medical record reviews and interviews of mothers. Saliva samples from each pair were collected between 9 and 60 days of age. The levels of testosterone and cortisol were determined by using an enzyme immunoassay methodology.
RESULTS: Linear regression analysis showed that neonatal health problems were positively associated with the levels of postnatal salivary testosterone and cortisol, while growth delays were positively associated with the levels of postnatal salivary testosterone after adjusting for the characteristics of neonates and mothers and day of saliva sampling. The salivary levels of testosterone and cortisol were higher in neonates than in mothers. A positive correlation between the levels of testosterone and cortisol was found in neonates and in mothers.
CONCLUSIONS: The level of postnatal salivary testosterone is a more reliable marker in assessing neonatal health and growth outcomes compared to salivary cortisol. Further research on both testosterone and cortisol measurements at various stages during the neonatal period may elucidate further these associations.
June I Cho; Waldemar A Carlo; Xiaogang Su; Kenneth L McCormick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-26
Journal Detail:
Title:  Early human development     Volume:  88     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-12-11     Revised Date:  2013-11-12    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  789-95     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ireland Ltd.
School of Nursing, University of Alabama at Birmingham, 35294, USA.
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MeSH Terms
Androgens / analysis
Anti-Inflammatory Agents / analysis
Hydrocortisone / analysis*
Infant, Newborn
Infant, Premature / growth & development,  metabolism
Infant, Very Low Birth Weight / growth & development,  metabolism*
Saliva / chemistry*
Sex Factors
Testosterone / analysis*
Grant Support
Reg. No./Substance:
0/Androgens; 0/Anti-Inflammatory Agents; 50-23-7/Hydrocortisone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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