Document Detail

Associations between reduced diffusing capacity and airflow obstruction in community-based subjects.
MedLine Citation:
PMID:  17481877     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The purpose of this analysis was to determine if abnormal diffusing capacity of the lung for carbon monoxide (DLco) identified a group of subjects with significantly different characteristics than those with normal lung function or airflow obstruction alone. METHODS: Participants were a random sample of adults aged 45-70 years. They completed a detailed respiratory questionnaire, spirometry, methacholine challenge and measurement of single breath DLco. Subjects were categorized into one of three groups: airflow obstruction only, reduced DLco only, or both airflow obstruction and reduced DLco. RESULTS: Individuals with airflow obstruction and reduced DLco in combination reported more symptoms than those with either condition alone. In subjects with a combination of both airflow obstruction and reduced DLco, a significantly higher proportion reported use of medication and laboratory tests. Current smoking was significantly associated with a reduced DLco alone and in combination with airflow obstruction, however, the association was stronger in those with DLco and airflow obstruction. Bronchial hyperreactivity (BHR) was found to be a risk factor while atopy was associated with a reduced risk of DLco and airflow obstruction. CONCLUSIONS: Reduced DLco plus airflow obstruction together identifies a group of individuals with significantly more symptoms and worse lung function. Current cigarette smoking, early life serious respiratory infection and BHR were strongly associated with reduced DLco in combination with airflow obstruction.
Melanie C Matheson; Joan Raven; David P Johns; Michael J Abramson; E Haydn Walters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-03
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-11-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1730-7     Citation Subset:  IM    
Department of Epidemiology and Preventive Medicine, Monash University, Vic., Australia.
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MeSH Terms
Airway Obstruction / epidemiology*
Bronchial Hyperreactivity / epidemiology*
Middle Aged
Pulmonary Diffusing Capacity / physiology*
Pulmonary Disease, Chronic Obstructive / epidemiology*
Respiratory Function Tests
Risk Factors
Smoking / adverse effects
Victoria / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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