Document Detail

Associations between popliteal artery wall thickness and knee structure in adults without clinical knee disease: A prospective cohort study.
MedLine Citation:
PMID:  25358676     Owner:  NLM     Status:  Publisher    
Objective: There is evidence for a vascular contribution to the pathogenesis of osteoarthritis. Our aim was to use an asymptomatic cohort to examine the association between popliteal artery wall thickness, previously shown to be associated with risk of osteoarthritis, and knee structural changes. Methods: 297 adults with no significant knee pain, injury, or history of clinical knee disease were recruited. Participants underwent knee magnetic resonance imaging at baseline and 2 years later. Popliteal artery wall thickness, knee cartilage volume and bone marrow lesions (BML) were assessed. Results: Of 278 participants with valid popliteal artery wall thickness measurement, 254 (91.4%) completed 2-year follow-up. After adjusting for age, gender, body mass index and tibial bone area, increased popliteal artery wall thickness was associated with reduced medial tibial cartilage volume (B = -6.7, 95% CI -12.9, -0.6, p=0.03) and increased rate of medial tibial cartilage volume loss (B=0.06, 95% CI 0.01, 0.12, p=0.03). There was a trend for medial tibiofemoral BML worsening in relation to increased popliteal artery wall thickness (odds ratio=1.07, 95% CI 0.99, 1.15, p=0.07). No significant associations were observed in lateral tibiofemoral compartment. Conclusion: Increased popliteal artery wall thickness was associated with adverse changes in knee structure, as evidenced by reduced medial tibial cartilage volume, increased rate of cartilage volume loss and a trend for BML worsening over 2 years. These findings suggest an association between vascular pathology and early knee structural changes, supporting the hypothesis that vascular health may play a role in the development of knee osteoarthritis. © 2014 American College of Rheumatology.
Yuanyuan Wang; Diaz Novera; Anita E Wluka; Jessica Fairley; Graham G Giles; Richard O'Sullivan; Flavia M Cicuttini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-30
Journal Detail:
Title:  Arthritis & rheumatology (Hoboken, N.J.)     Volume:  -     ISSN:  2326-5205     ISO Abbreviation:  -     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-31     Completed Date:  -     Revised Date:  2014-11-2    
Medline Journal Info:
Nlm Unique ID:  101623795     Medline TA:  Arthritis Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 American College of Rheumatology.
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