Document Detail


Associations between polymorphisms of the high-affinity immunoglobulin E receptor and late-onset airflow obstruction in older populations.
MedLine Citation:
PMID:  12919239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To test the hypothesis that genetic polymorphisms in the beta subunit of the high-affinity immunoglobulin E (IgE) receptor are associated with late-onset airflow obstruction. DESIGN: Case-control candidate gene association study. SETTING: Department of Medicine for the Elderly and Respiratory Medicine in three teaching hospitals in Leicester and Manchester, United Kingdom. PARTICIPANTS: Cases with late-onset airflow obstruction with age-, sex-, and geographically matched controls. MEASUREMENTS: Subjects were genotyped for two polymorphisms of the beta subunit of the high-affinity IgE receptor (RsaI intron 2 and RsaI exon 7). The association between the polymorphisms and phenotypes was examined using contingency tables and linear regression models. RESULTS: Two hundred eighty-three cases and 144 controls were genotyped. RsaI exon 7 AA was associated with eczema (odds ratio (OR)=2.27, 95% confidence interval (CI)=1.17-4.38, P=.015). No other associations were found. Total serum IgE levels were significantly higher in cases than controls (adjusted OR for high/low IgE=2.56, 95% CI=1.53-4.28, P<.001). CONCLUSION: Serum IgE levels, but not the high-affinity IgE receptor polymorphisms, were associated with late-onset airflow obstruction, suggesting that interaction between environmental and genetic factors controlling serum IgE levels and disease pathogenesis may differ between early- and late-onset airflow obstruction phenotypes.
Authors:
Charlotte E Ruse; Maureen C Hill; Paul R Burton; Martin J Connolly; Andrew J Wardlaw; Stuart G Parker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  51     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-15     Completed Date:  2003-10-20     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-9     Citation Subset:  IM    
Affiliation:
Institute for Lung Health, University of Leicester, Leicester, United Kingdom. charlotteruse@lycos.co.uk
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Asthma / blood,  diagnosis,  genetics,  physiopathology
Confidence Intervals
Eczema / genetics
Female
Forced Expiratory Volume
Genotype
Humans
Immunoglobulin E / blood*
Linear Models
Lung Diseases, Obstructive / blood,  diagnosis,  genetics*,  physiopathology
Male
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic*
Pulmonary Disease, Chronic Obstructive / blood,  diagnosis,  genetics,  physiopathology
Receptors, IgE / genetics*
Sex Factors
Spirometry
Time Factors
Chemical
Reg. No./Substance:
0/Receptors, IgE; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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