Document Detail

Associations between plasma homocysteine levels, aortic stiffness and wave reflection in patients with arterial hypertension, isolated office hypertension and normotensive controls.
MedLine Citation:
PMID:  19516272     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate any possible association of homocysteine with arterial stiffness indices in patients with essential arterial hypertension (AH), isolated office hypertension (IOH) and normotensive controls. The final cohort comprised 231 normotensives (NTs, 119 males), 480 patients with IOH (196 males) and 1188 patients with essential AH (713 males). All patients were screened for plasma homocysteine levels and lipidaemic profile and underwent aortic compliance and wave reflection assessment by using carotid-femoral pulse wave velocity (PWVc-f) and aortic augmentation index corrected for heart rate (AIx) accordingly. In the total population, stepwise multiple linear regression analysis showed that homocysteine levels remained a significant determinant of PWV (beta (SE): 0.056 (0.007), P<0.001) and AIx (beta (SE): 0.236 (0.052), P<0.001) independently of the traditional factors affecting arterial stiffness and wave reflection. When the three groups were examined separately, homocysteine levels remained an independent determinant of PWFc-f in all groups (NT: beta (SE): 0.070 (0.022), P=0.002; IOH: beta (SE): 0.109 (0.015), P<0.001; AH: beta (SE): 0.040 (0.009), P<0.001). However, homocysteine levels remained an independent determinant of AIx only in the IOH and AH, but not in the NT group (IOH: beta (SE): 0.302 (0.124), P=0.015; AH: beta (SE): 0.183 (0.057), P=0.001; NT: beta (SE): 0.308 (0.240), P=0.200). This study points to an independent relationship between circulating homocysteine levels, aortic compliance and wave reflection.
G Vyssoulis; E Karpanou; S-M Kyvelou; D Adamopoulos; T Gialernios; E Gymnopoulou; D Cokkinos; C Stefanadis
Publication Detail:
Type:  Journal Article     Date:  2009-06-11
Journal Detail:
Title:  Journal of human hypertension     Volume:  24     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-11     Completed Date:  2010-04-23     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-9     Citation Subset:  IM    
Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Aortic Diseases / blood,  epidemiology*,  physiopathology
Blood Pressure
Femoral Artery / physiology
Heart Rate
Homocysteine / blood*
Hyperhomocysteinemia / blood,  epidemiology*,  physiopathology
Hypertension / blood,  epidemiology*,  physiopathology
Linear Models
Middle Aged
Pulsatile Flow
Risk Factors
Smoking / epidemiology
Reg. No./Substance:

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