Document Detail

Associations between physical fitness and HbA₁(c) in type 2 diabetes mellitus.
MedLine Citation:
PMID:  20953579     Owner:  NLM     Status:  MEDLINE    
AIM/HYPOTHESIS: In people with type 2 diabetes, exercise improves glucose control (as reflected in HbA₁(c)) and physical fitness, but it is not clear to what extent these exercise-induced improvements are correlated with one another. We hypothesised that reductions in HbA₁(c) would be related: (1) to increases in aerobic fitness and strength respectively in patients performing aerobic training or resistance training; and (2) to changes in strength and aerobic fitness in patients performing aerobic and resistance training.
METHODS: We randomly allocated 251 type 2 diabetes patients to aerobic, resistance, or aerobic plus resistance training, or to a sedentary control group. Peak oxygen consumption VO₂(peak), workload, treadmill time and ventilatory threshold measurements from maximal treadmill exercise testing were measured at baseline and 6 months. Muscular strength was measured as the maximum weight that could be lifted eight times on the leg press, bench press and seated row exercises.
RESULTS: With aerobic training, significant associations were found between changes in both VO₂(peak) (p = 0.040) and workload (p = 0.022), and changes in HbA₁(c.) With combined training, improvements in VO₂(peak) (p = 0.008), workload (p = 0.034) and ventilatory threshold (p = 0.003) were significantly associated with changes in HbA₁(c.) Increases in strength on the seated row (p = 0.006) and in mid-thigh muscle cross-sectional area (p = 0.030) were significantly associated with changes in HbA₁(c) after resistance exercise, whereas the association between increases in muscle cross-sectional area and HbA₁(c) in participants doing aerobic plus resistance exercise (p = 0.059) was of borderline significance.
CONCLUSIONS/INTERPRETATION: There appears to be a link between changes in fitness and HbA₁(c). The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA₁(c) than improvements in strength.
J Larose; R J Sigal; F Khandwala; D Prud'homme; N G Boulé; G P Kenny;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-16
Journal Detail:
Title:  Diabetologia     Volume:  54     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-05-11     Revised Date:  2011-06-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
University of Ottawa, Montpetit Hall, ON, Canada.
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MeSH Terms
Diabetes Mellitus, Type 2 / metabolism*
Exercise / physiology
Hemoglobin A, Glycosylated / metabolism*
Middle Aged
Physical Fitness / physiology*
Grant Support
MCT-44155//Canadian Institutes of Health Research
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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