| Associations between physical fitness and HbA₁(c) in type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20953579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM/HYPOTHESIS: In people with type 2 diabetes, exercise improves glucose control (as reflected in HbA₁(c)) and physical fitness, but it is not clear to what extent these exercise-induced improvements are correlated with one another. We hypothesised that reductions in HbA₁(c) would be related: (1) to increases in aerobic fitness and strength respectively in patients performing aerobic training or resistance training; and (2) to changes in strength and aerobic fitness in patients performing aerobic and resistance training. METHODS: We randomly allocated 251 type 2 diabetes patients to aerobic, resistance, or aerobic plus resistance training, or to a sedentary control group. Peak oxygen consumption VO₂(peak), workload, treadmill time and ventilatory threshold measurements from maximal treadmill exercise testing were measured at baseline and 6 months. Muscular strength was measured as the maximum weight that could be lifted eight times on the leg press, bench press and seated row exercises. RESULTS: With aerobic training, significant associations were found between changes in both VO₂(peak) (p = 0.040) and workload (p = 0.022), and changes in HbA₁(c.) With combined training, improvements in VO₂(peak) (p = 0.008), workload (p = 0.034) and ventilatory threshold (p = 0.003) were significantly associated with changes in HbA₁(c.) Increases in strength on the seated row (p = 0.006) and in mid-thigh muscle cross-sectional area (p = 0.030) were significantly associated with changes in HbA₁(c) after resistance exercise, whereas the association between increases in muscle cross-sectional area and HbA₁(c) in participants doing aerobic plus resistance exercise (p = 0.059) was of borderline significance. CONCLUSIONS/INTERPRETATION: There appears to be a link between changes in fitness and HbA₁(c). The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA₁(c) than improvements in strength. |
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Authors:
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J Larose; R J Sigal; F Khandwala; D Prud'homme; N G Boulé; G P Kenny; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-10-16 |
Journal Detail:
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Title: Diabetologia Volume: 54 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-05-11 Revised Date: 2011-06-15 |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
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Languages: eng Pagination: 93-102 Citation Subset: IM |
Affiliation:
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University of Ottawa, Montpetit Hall, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Diabetes Mellitus, Type 2 / metabolism* Exercise / physiology Female Hemoglobin A, Glycosylated / metabolism* Humans Male Middle Aged Physical Fitness / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MCT-44155//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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