Document Detail


Associations between passive immunity and morbidity and mortality in dairy heifers in Florida, USA.
MedLine Citation:
PMID:  9541949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective cohort study was undertaken to determine calf-level factors that affected calf health status between birth and 6 months of age. A convenience sample of approximately 3300 female Holstein calves born in 1991 on two large Florida dairy farms was used for the study. Data collected on each calf at birth included farm of origin, weight, height at the pelvis, birth date, and serum total protein (a measure of colostral immunoglobulin absorption). Birth season was dichotomized into summer and winter using meteorological data collected by University of Florida Agricultural Research Stations. Health data including date of initial treatment and number of treatments were collected for the diseases diarrhea, omphalitis, septicemia and pneumonia. All calves were followed for 6 months. Cumulative incidences of mortality and occurrence of diarrhea, omphalitis, septicemia and pneumonia were 0.12, 0.35, 0.11, 0.24 and 0.21, respectively. Serum total protein (TP) was a significant risk factor for mortality. The association of TP and mortality was quadratic and showed a dramatic decrease in mortality as TP increased from 4.0 to 5.0 g/dl, a small improvement from 5.0 to 6.0 g/dl and virtually no improvement in mortality rates as TP increased over 6.0 g/dl. The hazard mortality ratio was constant from birth to six months, indicating that the increased risk of mortality associated with low levels of TP was evident through six months of age. No interactions between TP, farm, season, or birth weight were found in these analyses. Serum total protein concentration was a significant risk factor for the occurrences, age of onset and severity of septicemia and pneumonia. The association between TP and septicemia was linear and an interaction with birth season was found. The association between TP and pneumonia was quadratic, and in contrast to the TP-and-septicemia relationship, the morbidity hazard ratio for pneumonia was not constant over the time measured; that is, colostral immunity protected the calf from developing pneumonia early in life, but this effect disappeared as the calf got older. Total protein was not a significant risk factor for diarrhea or omphalitis.
Authors:
G A Donovan; I R Dohoo; D M Montgomery; F L Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  34     ISSN:  0167-5877     ISO Abbreviation:  Prev. Vet. Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-22     Completed Date:  1998-05-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-46     Citation Subset:  IM    
Affiliation:
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136, USA. art@rams.vetmed.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / immunology
Cattle
Cattle Diseases / epidemiology,  immunology*,  mortality*
Female
Florida / epidemiology
Health Status
Immunization, Passive / veterinary*
Incidence
Logistic Models
Prospective Studies
Seasons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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