| Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. | |
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MedLine Citation:
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PMID: 9494027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aldosterone has direct and indirect effects on the heart, and genetic variations in aldosterone synthesis could therefore influence cardiac structure and function. Such variations might be associated with polymorphisms in the gene encoding aldosterone synthase (CYP11B2), the enzyme catalyzing the last steps of aldosterone biosynthesis. METHODS AND RESULTS: A Finnish population sample of 84 persons (44 women) aged 36 to 37 years was studied by M-mode and Doppler echocardiography to assess left ventricular size, mass, and function. Subjects were genotyped through the use of the polymerase chain reaction for two diallelic polymorphisms in CYP11B2: one in the transcriptional regulatory region (promoter) and the other in the second intron. In multiple regression analyses, the CYP11B2 promoter genotype predicted statistically significant variations in left ventricular end-diastolic diameter (beta=.40, P<.0001), end-systolic diameter (beta=.33, P=.0009), and mass (beta=.17, P=.023). These effects were independent of potentially confounding factors, including sex, body size, blood pressure, physical activity, smoking, and ethanol consumption. Genotype groups also differed in a measure of left ventricular diastolic function, the heart rate-adjusted atrial filling fraction (P=.018). Increased dietary salt, which is known to predict increased left ventricular mass, had this effect only in association with certain CYP11B2 genotypes (P<.001). CONCLUSIONS: Genetic variations in or near the aldosterone synthase (CYP11B2) gene strongly affect left ventricular size and mass in young adults free of clinical heart disease. These polymorphisms may also influence the response of the left ventricle to increases in dietary salt. |
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Authors:
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M Kupari; A Hautanen; L Lankinen; P Koskinen; J Virolainen; H Nikkila; P C White |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 97 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-10 Completed Date: 1998-03-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-75 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Helsinki University Central Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone Synthase / genetics* Echocardiography Echocardiography, Doppler Female Genotype Heart Ventricles / anatomy & histology*, drug effects Humans Male Polymorphism, Genetic* Regression Analysis Sodium, Dietary / pharmacology Statistics as Topic Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK37867/DK/NIDDK NIH HHS; DK42169/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; EC 1.14.15.4/Aldosterone Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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