Document Detail


Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women.
MedLine Citation:
PMID:  23018377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.
Authors:
Caroline Mitchell; Jennifer E Balkus; Jennifer McKernan-Mullin; Susan E Cohn; Amneris E Luque; Christina Mwachari; Craig R Cohen; Robert Coombs; Lisa M Frenkel; Jane Hitti
Related Documents :
24709727 - Surveying the surveillance: surgical site infections excluded by the january 2013 updat...
24330517 - Host serum mir-223 is a potential new biomarker for schistosoma japonicum infection and...
23820207 - Emergence of virulent pseudorabies virus infection in northern china.
22978517 - Antihistomonal effects of artemisinin and artemisia annua extracts in vitro could not b...
24709727 - Surveying the surveillance: surgical site infections excluded by the january 2013 updat...
9581877 - Heterosexual transmission of human immunodeficiency virus type 1 (hiv): interactions of...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  62     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-03-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM; X    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Retroviral Agents / therapeutic use
CD4 Lymphocyte Count
Cervix Uteri / metabolism,  virology*
Cytomegalovirus Infections / complications
DNA, Viral / isolation & purification*
Female
HIV Infections / complications,  drug therapy,  virology*
HIV-1 / isolation & purification*
Herpes Genitalis / complications
Humans
Interleukin-1 / metabolism
Interleukin-1beta / metabolism
Interleukin-8 / metabolism
Kenya
Middle Aged
Prospective Studies
RNA, Viral / blood,  isolation & purification
Reproductive Tract Infections / complications,  microbiology,  virology
United States
Uterine Cervicitis / complications,  metabolism
Vagina / metabolism,  microbiology,  virology*
Vaginitis / complications,  metabolism,  microbiology
Viral Load
Grant Support
ID/Acronym/Agency:
1R21AI080439-01A1/AI/NIAID NIH HHS; HD-01-264/HD/NICHD NIH HHS; K12 HD001264/HD/NICHD NIH HHS; P01 HD040540/HD/NICHD NIH HHS; P01HD40540/HD/NICHD NIH HHS; R21 AI080439/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/DNA, Viral; 0/Interleukin-1; 0/Interleukin-1beta; 0/Interleukin-8; 0/RNA, Viral
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monitoring HIV testing at visits to emergency departments in the United States: Very low rate of HIV...
Next Document:  NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but main...