Document Detail

Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma.
MedLine Citation:
PMID:  20435859     Owner:  NLM     Status:  MEDLINE    
BACKGROUND The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E. METHODS A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown-rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma alpha-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured. RESULTS CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV(1); 5 ml increase in FEV(1) per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25% and 75% of FVC (FEF(25-75); 0.008 ml/s increase in FEF(25-75) per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma alpha-tocopherol (p=0.002). CONCLUSIONS These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.
Stephen W Turner; Doris Campbell; Norman Smith; Leone C A Craig; Geraldine McNeill; Sarah H Forbes; Paul J Harbour; Anthony Seaton; Peter J Helms; Graham S Devereux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  65     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Department of Child Health, University of Aberdeen, Royal Aberdeen Children's Hospital, Foresterhill, Aberdeen AB25 2ZG, UK.
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MeSH Terms
Anthropometry / methods
Asthma / embryology*,  physiopathology
Birth Weight / physiology
Child, Preschool
Cohort Studies
Crown-Rump Length
Fetal Development / physiology*
Forced Expiratory Volume
Hypersensitivity, Immediate / embryology
Infant, Newborn
Longitudinal Studies
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena / physiology
Respiratory Sounds / physiopathology
Ultrasonography, Prenatal
Vital Capacity
alpha-Tocopherol / blood*
Reg. No./Substance:

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