Document Detail

Associations between dietary flavonoid intakes and bone health in a Scottish population.
MedLine Citation:
PMID:  21089133     Owner:  NLM     Status:  Publisher    
BACKGROUND: Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of peri-menopausal Scottish women. METHODS: Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study. The diets were analysed for flavonoid intakes using a food composition database. BMD was measured at the femoral neck (FN) and lumbar spine (LS) by DXA. Free pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by HPLC in second early morning fasted urine samples. RESULTS: The mean flavonoid intake of the diet was 307 ±199 mg/d. The catechin family contributed the most to flavonoid intakes (55%), and the flavones the least (<1%). Associations were found between energy adjusted total flavonoid intakes and BMD at the FN and LS (FN r=0.054. LS r=0.036, p= 0.05). Annual % change in BMD was associated with intakes of procyanidins and catechins (p=0.05), and flavanones were negatively associated with bone resorption markers (PYD r=-0.049. DPD r=-0.057, p=0.001). These associations were still seen after adjusting for confounders. CONCLUSION: Dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies. © 2010 American Society for Bone and Mineral Research.
Antonia C Hardcastle; Lorna Aucott; David M Reid; Helen M Macdonald
Related Documents :
12067043 - Interpreting and using the dietary references intakes in dietary assessment of individu...
8610083 - Consumption of foods and micronutrients and the risk of cancer of the biliary tract.
17993953 - Optimal plaster conformation derived using a custom-made jig to obtain maximum strength...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-18
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  -     ISSN:  1523-4681     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Bone and Musculoskeletal Research Programme, Health Sciences Building, University of Aberdeen, Foresterhill, Aberdeen. AB25 2ZD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  What are the cut-off levels for IL-6 and CRP in neonatal sepsis?
Next Document:  Serum uric acid is associated with bone health in older men: A cross-sectional, population-based stu...