| Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. | |
| | |
MedLine Citation:
|
PMID: 20216092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Microvascular dysfunction may be an early precursor of cardiovascular disease (CVD). Increased left ventricular mass (LVM), concentric left ventricular remodelling and increased left atrial size are the factors that could predict future CVD. We investigated whether microvascular dysfunction was associated with these cardiac measures. METHODS AND RESULTS: Laser Doppler fluximetry of skin vessels was used to study associations with risk factors and echocardiographic measurements of LVM, relative wall thickness (RWT), and left atrial size in 305 people (aged 40-65 years; 117 with type 2 diabetes). Flow in response to a 3-min arterial occlusion was measured. Postischaemic peak flow responses were categorized into three distinct groups: slow rise to peak (normal), nondominant early peak group (mildly abnormal) and a dominant early peak (abnormal). Those with a dominant early peak had higher blood pressure (P = 0.001), weight (P = 0.001), fasting glucose (P = 0.001) and prevalence of diabetes (P = 0.02). LVM (P = 0.01), RWT (P < 0.001) and left atrial size (P < 0.001) were greater with worsening postischaemic peak flow responses. Differences in LVM between postischaemic response groups were accounted for by blood pressure (BP). However, differences in BP and other CVD risk factors did not account for the greater RWT and left atrial size observed in the more adverse peak response groups [geometric mean of RWT [95% confidence interval (CI)] 0.40 (0.38-0.41) vs. 0.41 (0.40-0.42) vs. 0.43 (0.41-0.45), P = 0.007; left atrial size 36.1 (35.4-36.1) vs. 37.4 (36.8-38.0) vs. 38.7 (37.5-40.0), P = 0.002 for normal vs. mildly abnormal vs. abnormal respectively]. CONCLUSION: An abnormal microcirculatory cutaneous peak flow response following ischaemia is associated with adverse cardiac remodelling, independent of CVD risk factors including blood pressure. |
| | |
Authors:
|
William D Strain; Nish Chaturvedi; Alun Hughes; Petros Nihoyannopoulos; Christopher J Bulpitt; Chakravarthi Rajkumar; Angela C Shore |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-16 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 952-8 Citation Subset: IM |
Affiliation:
|
Institute of Biomedical and Clinical Science, Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, Exeter, UK. david.strain@pms.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Pressure / physiology* Diabetes Mellitus, Type 2 / physiopathology* Diabetic Angiopathies / physiopathology* Female Humans Hypertension / physiopathology Hypertrophy, Left Ventricular / pathology, physiopathology Ischemia / physiopathology Laser-Doppler Flowmetry Male Microcirculation / physiology* Middle Aged Risk Factors Skin / blood supply* Ventricular Remodeling / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to a...
Next Document: Congenital Diarrheal Disorders: Improved Understanding of Gene Defects Is Leading to Advances in Int...