Document Detail


Associations between body composition and bone density and structure in men and women across the adult age spectrum.
MedLine Citation:
PMID:  23238122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: The objective of this study was to identify independent associations between body composition and bone outcomes, including cortical structure and cortical and trabecular volumetric bone mineral density (vBMD) across the adult age spectrum.
METHODS: This cross-sectional study evaluated over 400 healthy adults (48% male, 44% black race), ages 21-78years. Multivariable linear regression models evaluated associations between whole-body DXA measures of lean body mass index (LBMI) and fat mass index (FMI) and tibia peripheral quantitative CT (pQCT) measures of cortical section modulus, cortical and trabecular vBMD and muscle density (as a measure of intramuscular fat), adjusted for age, sex, and race. All associations reported below were statistically significant (p<0.05).
RESULTS: Older age and female sex were associated with lower LBMI and muscle strength. Black race was associated with greater LBMI but lower muscle density. Greater FMI was associated with lower muscle density. Cortical section modulus was positively associated with LBMI and muscle strength and negatively associated with FMI. Adjustment for body composition eliminated the greater section modulus observed in black participants and attenuated the lower section modulus in females. Greater LBMI was associated with lower cortical BMD and greater trabecular BMD. FMI was not associated with either BMD outcome. Greater muscle density was associated with greater trabecular and cortical BMD. Associations between body composition and bone outcomes did not vary by sex (no significant tests for interaction).
CONCLUSIONS: These data highlight age-, sex- and race-specific differences in body composition, muscle strength and muscle density, and demonstrate discrete associations with bone density and structure. These data also show that age-, sex- and race-related patterns of bone density and strength are independent of differences in body composition. Longitudinal studies are needed to examine the temporal relations between changes in bone and body composition.
Authors:
Joshua F Baker; Matthew Davis; Ruben Alexander; Babette S Zemel; Sogol Mostoufi-Moab; Justine Shults; Michael Sulik; Daniel J Schiferl; Mary B Leonard
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-11
Journal Detail:
Title:  Bone     Volume:  53     ISSN:  1873-2763     ISO Abbreviation:  Bone     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-08-16     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-41     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors*
Aged
Body Composition*
Body Mass Index
Bone Density*
Female
Humans
Male
Middle Aged
Muscle Strength
Tomography, X-Ray Computed
Young Adult
Grant Support
ID/Acronym/Agency:
K24 DK076808/DK/NIDDK NIH HHS; K24DK076808/DK/NIDDK NIH HHS; R01 DK064966/DK/NIDDK NIH HHS; R01DK064966/DK/NIDDK NIH HHS; UL1 RR024134/RR/NCRR NIH HHS; UL1-RR024134/RR/NCRR NIH HHS
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