| Associations between blood metals and fecundity among women residing in New York State. | |
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MedLine Citation:
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PMID: 20933593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 menstrual cycles at risk for pregnancy; home pregnancy test kits were used. For 80 women, whole blood specimens were analyzed for arsenic, cadmium, lead, magnesium, nickel, selenium and zinc using inductively coupled plasma mass spectrometry (ICP-MS). Time to pregnancy was estimated using Cox proportional hazards models for discrete time. Metal concentrations were generally within population reference intervals. Adjusted models suggest a 51.5% increase in the probability for pregnancy per 3.60 μg/L increase in Mg (P=0.062), and a 27.7% decrease per 0.54 μg/L increase in Zn (P=0.114). Findings indicate that Mg and Zn may impact female fecundity, but in varying directions. |
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Authors:
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Michael S Bloom; Germaine M Buck Louis; Rajeshwari Sundaram; Paul J Kostyniak; Jinesh Jain |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2010-10-08 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 31 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-07-07 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 158-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY 12144, USA. mbloom@uamail.albany.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arsenic / blood Cadmium / blood Female Fertility / physiology* Humans Lead / blood Magnesium / blood Metals / blood* New York Nickel / blood Pregnancy Prospective Studies Selenium / blood Time Factors Zinc / blood |
| Grant Support | |
ID/Acronym/Agency:
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ZIA HD008729-09/HD/NICHD NIH HHS; ZIA HD008883-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Metals; 7439-92-1/Lead; 7439-95-4/Magnesium; 7440-02-0/Nickel; 7440-38-2/Arsenic; 7440-43-9/Cadmium; 7440-66-6/Zinc; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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