Document Detail

Associations between bladder cancer risk factors and tumor stage and grade at diagnosis.
MedLine Citation:
PMID:  8172997     Owner:  NLM     Status:  MEDLINE    
Using data on 1,860 bladder cancer cases and 3,934 population-based controls from the National Bladder Cancer Study, we examined associations between suspected bladder cancer risk factors and tumor stage and grade. Employment in a high-risk occupation was associated with the entire clinical spectrum of bladder cancer rather than a particular tumor stage or grade. For example, relative risks (RR) were similar for noninvasive and invasive disease (1.5 and 1.6, respectively). Cigarette smoking also increased risk of the entire clinical spectrum of bladder cancer, but the more advanced the stage, the stronger the effect. For example, relative risks of noninvasive and invasive bladder cancer for current heavy smokers were 3.0 and 5.2, respectively. Cigarette smoking was associated with higher risk of low-grade than high-grade tumors, once stage of disease was taken into account. Compared with whites, nonwhites were at a lower risk of noninvasive bladder cancer (RR = 0.4) but at similar risk of invasive bladder cancer (RR = 1.1), a pattern indicating racial differences in health practices related to bladder cancer detection. History of urinary tract infections and bladder stones was associated with increasing relative risks for advanced tumor stage. Heavy artificial sweetener use was associated with higher-grade, poorly differentiated tumors. Coffee consumption and family history of bladder cancer were not consistently associated with tumor stage or grade. Overall, different clinical presentations of bladder cancer share most suspected bladder cancer risk factors, including employment in a high-risk occupation and cigarette smoking.
S R Sturgeon; P Hartge; D T Silverman; A F Kantor; W M Linehan; C Lynch; R N Hoover
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  5     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-25     Citation Subset:  IM    
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Continental Population Groups
Educational Status
Middle Aged
Neoplasm Staging
Occupational Diseases / complications
Risk Factors
Saccharin / adverse effects
Smoking / adverse effects
United States / epidemiology
Urinary Bladder Calculi / complications
Urinary Bladder Neoplasms / epidemiology,  etiology*,  pathology*
Urinary Tract Infections / complications
Reg. No./Substance:
0/Coffee; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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