Document Detail


Associations between baseline allergens and polysensitization.
MedLine Citation:
PMID:  18759876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Identification of patients at risk of developing polysensitization is not possible at present. An association between weak sensitizers and polysensitization has been hypothesized. OBJECTIVES: To examine associations of 21 allergens in the European baseline series to polysensitization. PATIENTS/METHODS: From a database-based study with 14 998 patients patch tested with the European baseline series between 1985 and 2005, a group of 759 (5.1%) patients were polysensitized. Odds ratios were calculated to determine the relative contribution of each allergen to polysensitization. RESULTS: Seven allergens--parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies. CONCLUSIONS: No common denominator for the association between the allergens and the polysensitization was apparent, and any association, whether positive or negative, was relatively low. Based on these results, sensitization to specific baseline allergens cannot be used as risk indicators for polysensitization.
Authors:
Berit Christina Carlsen; Torkil Menné; Jeanne Duus Johansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  59     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark. bccarlsen@dadlnet.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / administration & dosage,  diagnostic use*
Cobalt / diagnostic use
Denmark
Dermatitis, Allergic Contact / diagnosis*,  etiology
Disease Susceptibility / diagnosis*,  etiology
Female
Humans
Hypersensitivity, Immediate
Longitudinal Studies
Male
Methanol / diagnostic use
Middle Aged
Myroxylon
Parabens / diagnostic use
Patch Tests / methods*
Phenylenediamines / diagnostic use
Potassium Dichromate / diagnostic use
Probability
Risk Assessment
Sensitivity and Specificity
Sesquiterpenes / diagnostic use
Chemical
Reg. No./Substance:
0/Allergens; 0/Parabens; 0/Phenylenediamines; 0/Sesquiterpenes; 101-72-4/N-isopropyl-N-phenyl-4-phenylenediamine; 67-56-1/Methanol; 7440-48-4/Cobalt; 7646-79-9/cobaltous chloride; 7778-50-9/Potassium Dichromate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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