| Associations between back pain history and lumbar MRI findings. | |
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MedLine Citation:
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PMID: 12642766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY DESIGN: Retrospective monozygotic twin cohort study. OBJECTIVES: Our goal was to investigate the associations between different spinal MRI findings and current, past year, and lifetime low back pain after adjusting for occupational physical loading, smoking, genetics, and early family influences. SUMMARY OF BACKGROUND DATA: The role of spinal pathology in back symptoms continues to be controversial. METHODS: The study participants consisted of 115 monozygotic male twin pairs 35 to 69 years of age. The qualitatively assessed MRI parameters were as follows: disc height, bulging, herniations, anular tears, osteophytes, spinal stenosis, and endplate changes. Signal intensity was measured quantitatively. RESULTS: After controlling for age, disc height was associated with all back pain variables studied and anular tears with LBP frequency and intensity during the 12 months before imaging. Both were associated with lifetime frequency of low back pain interfering with daily activities, disability, and intensity of the worst lifetime pain episode. Other MRI findings did not explain the various symptom histories. Adjusting for physical loading in the past 12 months increased the associations of anular tears and "low back pain today" and 12-month low back pain parameters. After controlling for genotype and other familial influences, the within-pair differences in disc height and anular tears accounted for 6% to 12% of the total variance in the within-pair differences of low back pain variables. CONCLUSION: These findings raise new questions about the underlying mechanisms of LBP. The sensitivities of the only significant MRI parameters, disc height narrowing and anular tears, are poor, and these findings alone are of limited clinical importance. |
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Authors:
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Tapio Videman; Michele C Battié; Laura E Gibbons; Kenneth Maravilla; Hannu Manninen; Jaakko Kaprio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Twin Study |
Journal Detail:
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Title: Spine Volume: 28 ISSN: 1528-1159 ISO Abbreviation: Spine Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-18 Completed Date: 2003-03-28 Revised Date: 2009-07-09 |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: United States |
Other Details:
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Languages: eng Pagination: 582-8 Citation Subset: IM |
Affiliation:
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University of Alberta, Edmonton, Alberta, Canada. tapio.videman@ualberta.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Back Pain / diagnosis*, epidemiology Causality Cluster Analysis Cohort Studies Comorbidity Finland / epidemiology Humans Intervertebral Disk / pathology Intervertebral Disk Displacement / diagnosis, epidemiology Lumbosacral Region Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Odds Ratio Prevalence Retrospective Studies Risk Factors Spinal Diseases / diagnosis*, epidemiology Twins, Monozygotic |
| Grant Support | |
ID/Acronym/Agency:
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AR 40857/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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