Document Detail


Associations between apolipoprotein E gene polymorphism and plasminogen activator inhibitor-1 and atherogenic lipid profile in dialysis patients.
MedLine Citation:
PMID:  17763167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Apolipoprotein-E (ApoE) gene polymorphism has an important role in lipoprotein metabolism and could participate in the development of cardiovascular diseases (CVD). Plasminogen activator inhibitor-1 (PAI-1) is also regarded as a risk factor for CVD. The aim of the present study is to further investigate the possible link(s) between ApoE gene polymorphism and plasma PAI-1 antigen and serum lipid profile in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL AND METHODS: We studied 72 PD patients (38 female, mean age 49.9 +/- 16.1 years), 72 HD patients (22 female, mean age 57.4 +/- 14.6 years), and 42 healthy subjects (21 female, mean age 50.1 +/- 18.6 years). Serum lipid parameters, plasma PAI-1 levels, and ApoE genotypes were determined in all subjects. RESULTS: The distribution of ApoE genotypes and alleles frequencies was similar in dialysis patients and healthy controls. In PD patients, total cholesterol (TC), low-density lipoprotein (LDL)-C, and ApoB levels were significantly higher than that of HD patients. HD patients with E3/4 genotype had elevated TC, LDL-C and ApoB levels compared with E3/3 genotype. TC and triglyceride levels were also higher in E3/4 genotype than that of E2/3 genotype. PD and HD patients showed a significantly increased PAI-1 levels compared with controls, whereas PAI-1 levels were highest in HD patients. There was no significant relation between ApoE genotypes and PAI-1 levels. CONCLUSIONS: The present study suggests that ApoE polymorphism significantly affects serum lipid profile in HD patients and epsilon4 allele carriers are more susceptible to have atherogenic lipid profile.
Authors:
Hakki Arikan; Mehmet Koc; Hakan Sari; Serhan Tuglular; Cetin Ozener; Emel Akoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  29     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-11-05     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-9     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Department of Medicine, Marmara Medical School, Istanbul, Turkey. ihakkiarikan@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins E / genetics*
Atherosclerosis / blood,  etiology
Female
Gene Frequency
Genotype
Humans
Kidney Failure, Chronic / blood,  complications,  genetics
Lipids / blood*
Male
Middle Aged
Peritoneal Dialysis*
Plasminogen Activator Inhibitor 1 / blood*
Polymorphism, Genetic*
Renal Dialysis*
Risk Factors
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Lipids; 0/Plasminogen Activator Inhibitor 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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