| Associations between apolipoprotein E gene polymorphism and plasminogen activator inhibitor-1 and atherogenic lipid profile in dialysis patients. | |
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MedLine Citation:
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PMID: 17763167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Apolipoprotein-E (ApoE) gene polymorphism has an important role in lipoprotein metabolism and could participate in the development of cardiovascular diseases (CVD). Plasminogen activator inhibitor-1 (PAI-1) is also regarded as a risk factor for CVD. The aim of the present study is to further investigate the possible link(s) between ApoE gene polymorphism and plasma PAI-1 antigen and serum lipid profile in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL AND METHODS: We studied 72 PD patients (38 female, mean age 49.9 +/- 16.1 years), 72 HD patients (22 female, mean age 57.4 +/- 14.6 years), and 42 healthy subjects (21 female, mean age 50.1 +/- 18.6 years). Serum lipid parameters, plasma PAI-1 levels, and ApoE genotypes were determined in all subjects. RESULTS: The distribution of ApoE genotypes and alleles frequencies was similar in dialysis patients and healthy controls. In PD patients, total cholesterol (TC), low-density lipoprotein (LDL)-C, and ApoB levels were significantly higher than that of HD patients. HD patients with E3/4 genotype had elevated TC, LDL-C and ApoB levels compared with E3/3 genotype. TC and triglyceride levels were also higher in E3/4 genotype than that of E2/3 genotype. PD and HD patients showed a significantly increased PAI-1 levels compared with controls, whereas PAI-1 levels were highest in HD patients. There was no significant relation between ApoE genotypes and PAI-1 levels. CONCLUSIONS: The present study suggests that ApoE polymorphism significantly affects serum lipid profile in HD patients and epsilon4 allele carriers are more susceptible to have atherogenic lipid profile. |
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Authors:
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Hakki Arikan; Mehmet Koc; Hakan Sari; Serhan Tuglular; Cetin Ozener; Emel Akoglu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 29 ISSN: 0886-022X ISO Abbreviation: Ren Fail Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-31 Completed Date: 2007-11-05 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: United States |
Other Details:
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Languages: eng Pagination: 713-9 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, Marmara Medical School, Istanbul, Turkey. ihakkiarikan@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins E / genetics* Atherosclerosis / blood, etiology Female Gene Frequency Genotype Humans Kidney Failure, Chronic / blood, complications, genetics Lipids / blood* Male Middle Aged Peritoneal Dialysis* Plasminogen Activator Inhibitor 1 / blood* Polymorphism, Genetic* Renal Dialysis* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Lipids; 0/Plasminogen Activator Inhibitor 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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