Document Detail


Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative.
MedLine Citation:
PMID:  18332316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004.
DESIGN: A total of 1802 women aged 50 to 79 years in Iowa, Wisconsin, and Oregon with intakes of lutein and zeaxanthin above the 78th (high) and below the 28th (low) percentiles in the Women's Health Initiative Observational Study (1994-1998) were recruited 4 to 7 years later (2001-2004) into the Carotenoids in Age-Related Eye Disease Study.
RESULTS: Women in the group with high dietary levels of lutein and zeaxanthin had a 23% lower prevalence of nuclear cataract (age-adjusted odds ratio, 0.77; 95% confidence interval, 0.62-0.96) compared with those with low levels. Multivariable adjustment slightly attenuated the association (odds ratio, 0.81; 95% confidence interval, 0.65-1.01). Women in the highest quintile category of diet or serum levels of lutein and zeaxanthin as compared with those in the lowest quintile category were 32% less likely to have nuclear cataract (multivariable-adjusted odds ratio, 0.68; 95% confidence interval, 0.48-0.97; P for trend = .04; and multivariable-adjusted odds ratio, 0.68; 95% confidence interval, 0.47-0.98; P for trend = .01, respectively). Cross-sectional associations with macular pigment density were inverse but not statistically significant.
CONCLUSIONS: Diets rich in lutein and zeaxanthin are moderately associated with decreased prevalence of nuclear cataract in older women. However, other protective aspects of such diets may in part explain these relationships.
Authors:
Suzen M Moeller; Rick Voland; Lesley Tinker; Barbara A Blodi; Michael L Klein; Karen M Gehrs; Elizabeth J Johnson; D Max Snodderly; Robert B Wallace; Richard J Chappell; Niyati Parekh; Cheryl Ritenbaugh; Julie A Mares; ;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  126     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-04-24     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  354-64     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging*
Cataract / blood,  epidemiology*
Diet*
Female
Humans
Lens Nucleus, Crystalline / pathology*
Lutein / administration & dosage*,  blood
Middle Aged
Prevalence
Prospective Studies
Retinal Pigments / metabolism
Risk Factors
Women's Health*
Xanthophylls / administration & dosage*,  blood
Grant Support
ID/Acronym/Agency:
DK07665/DK/NIDDK NIH HHS; EY13018/EY/NEI NIH HHS; R01 EY016886/EY/NEI NIH HHS; U10 EY013018/EY/NEI NIH HHS; U10 EY013018-01/EY/NEI NIH HHS; U10 EY013018-02/EY/NEI NIH HHS; U10 EY013018-03/EY/NEI NIH HHS; U10 EY013018-04/EY/NEI NIH HHS; U10 EY013018-05/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Retinal Pigments; 0/Xanthophylls; 144-68-3/zeaxanthin; X72A60C9MT/Lutein
Investigator
Investigator/Affiliation:
Catherine Allen / ; Barbara A Blodi / ; Matthew Davis / ; Larry Hubbard / ; Tara LaRowe / ; Niyati Parekh / ; Karen M Gehrs / ; Robert Wallace / ; Elizabeth J Johnson / ; Jean Mayer / ; Michael L Klein / ; Cheryl Ritenbaugh / ; D Max Snodderly / ; Amy Millen / ; Bill Wooten / ; Paula Smith / ; Susan K Nolte / ; Debora Vahrenwald / ; Kelly O'Berry / ; Heather Stockman / ; Steven Wallace / ; Lindsey Fuhrmeister / ; Jane Armstrong / ; Michael Neider / ; Hugh Wabers / ; Janet Rowley / ; Tanya Judge / ; Lisa Oxton / ; Rickie Voland / ; Gail Ostrowski / ; Scott Burfield / ; Julie Ewing / ; Tracy Perkins / ; Barbara Alving / ; Jacques Rossouw / ; Shari Ludlam / ; Linda Pottern / ; Joan McGowan / ; Leslie Ford / ; Nancy Geller / ; Ross Prentice / ; Garnet Anderson / ; Andrea LaCroix / ; Charles L Kooperberg / ; Ruth E Patterson / ; Anne McTiernan / ; Sally Shumaker / ; Steven Cummings / ; Sylvia Wassertheil-Smoller / ; Jennifer Hays / ; JoAnn Manson / ; Annlouise R Assaf / ; Lawrence Phillips / ; Shirley Beresford / ; Judith Hsia / ; Rowan Chlebowski / ; Evelyn Whitlock / ; Bette Caan / ; Jane Morley Kotchen / ; Barbara V Howard / ; Linda Van Horn / ; Henry Black / ; Marcia L Stefanick / ; Dorothy Lane / ; Rebecca Jackson / ; Cora E Lewis / ; Tamsen Bassford / ; Jean Wactawski-Wende / ; John Robbins / ; F Allan Hubbell / ; Howard Judd / ; Robert D Langer / ; Margery Gass / ; Marian Limacher / ; David Curb / ; Robert Wallace / ; Judith Ockene / ; Norman Lasser / ; Mary Jo O'Sullivan / ; Karen Margolis / ; Robert Bruner / ; Gerardo Heiss / ; Lewis Kuller / ; Karen C Johnson / ; Robert Brzyski / ; Gloria E Sarto / ; Denise Bonds / ; Susan Hendrix /
Comments/Corrections

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