Document Detail

Associations between healthy lifestyle behaviors and proteinuria and the estimated glomerular filtration rate (eGFR).
MedLine Citation:
PMID:  22785025     Owner:  NLM     Status:  MEDLINE    
AIM: The aim was to investigate the respective associations between lifestyle and proteinuria and the estimated glomerular filtration rate (eGFR).
METHODS: The lifestyle habits of 25,493 middle-aged participants were investigated in a cross-sectional study to find habits that are associated with a low eGFR (<60 mL/min/1.73 m(2)) and/or the presence of proteinuria. The lifestyle habits of the participants were evaluated using a questionnaire. Unhealthy lifestyle habits were defined as follows: 1. obesity, 2. being a current/former smoker, 3. eating irregular meals, 4. having less than 5 hours sleep, 5. exercising less than once a week, and 6. drinking more than once a week. The associations among unhealthy habits, eGFR, and proteinuria were evaluated using multivariate analysis.
RESULTS: The following lifestyle factors were significantly and independently associated with proteinuria: obesity (odds ratio (OR): 1.18, 95%C.I: 1.04-1.34), being a current/former smoker (OR: 1.26, 95%C.I: 1.11-1.42), eating irregular meals (OR: 1.40, 95%C.I: 1.22-1.61), sleeping less than 5 hours (OR: 1.38, 95%C.I: 1.15-1.65), and exercising less than once a week (OR: 1.18, 95%C.I: 1.05-1.33). In contrast, the following unhealthy lifestyle factors were not clearly associated with a low eGFR: obesity (OR: 1.05, 95%C.I: 0.95-1.17), being a current/former smoker (OR: 0.76, 95%C.I: 0.69-0.84), eating irregular meals (OR: 0.91, 95%C.I: 0.79-1.04), sleeping less than 5 hours (OR: 1.02, 95%C.I: 0.85-1.22), and exercising less than once a week (OR: 0.91, 95%C.I: 0.83-0.99).
CONCLUSION: Associations between proteinuria and unhealthy lifestyle habits were observed in our cross-sectional study. Unhealthy lifestyles should be monitored during the management of CKD patients with proteinuria.
Kazutoshi Fujibayashi; Hiroshi Fukuda; Hirohide Yokokawa; Tomomi Haniu; Fukuko Oka; Miki Ooike; Toshiaki Gunji; Noriko Sasabe; Mitsue Okumura; Kimiko Iijima; Teruhiko Hisaoka; Hiroshi Isonuma
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Publication Detail:
Type:  Journal Article     Date:  2012-07-05
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  19     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-02     Completed Date:  2013-04-12     Revised Date:  2013-07-16    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  932-40     Citation Subset:  IM    
Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan.
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MeSH Terms
Alcohol Drinking / adverse effects
Cross-Sectional Studies
Glomerular Filtration Rate*
Health Behavior
Life Style*
Middle Aged
Obesity / complications
Proteinuria / physiopathology*
Renal Insufficiency, Chronic / physiopathology*,  psychology*
Risk Factors
Smoking / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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