Document Detail

Associations between common genetic polymorphisms in angiopoietin-like proteins 3 and 4 and lipid metabolism and adiposity in European adolescents and adults.
MedLine Citation:
PMID:  19890028     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Plasma-borne angiopoietin-like proteins (ANGPTL) act as endocrine factors on their target tissues. Because ANGPTL3 and ANGPTL4 play important roles in lipid metabolism and the regulation of adiposity in mice, we hypothesized that genetic variability at the ANGPTL3 and ANGPTL4 genes loci might influence lipid metabolism and fat deposition in humans. OBJECTIVE: The aim of the study was to examine the association between ANGPTL3 and ANGPTL4 genetic polymorphisms and metabolic phenotypes in adolescent and adult samples. DESIGN AND PARTICIPANTS: Two independent population-based studies, one composed of 1144 adolescents (mean age, 14.8 +/- 1.4 yr) from nine European countries (the HELENA study) and the other composed of 1155 adults (age range, 35-65 yr) from Northern France (the MONICA Lille study), were genotyped for one ANGPTL3 polymorphism and four ANGPTL4 polymorphisms. RESULTS: The ANGPTL3 rs11207997 polymorphism (minor allele frequency, 0.32) was associated with lower plasma HDL-cholesterol and apolipoprotein A-I levels in both adolescents (P = 0.0004, P = 0.00006, respectively) and adults (P = 0.03, P = 0.02, respectively). The ANGPTL4 rs4076317 polymorphism (minor allele frequency, 0.29) was associated with a higher percentage of body fat (P = 0.02) in adolescents and a higher waist-to-hip ratio (in interaction with the peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism) in adults (P = 0.0004). CONCLUSION: The present study underlines the role of ANGPTL3 in HDL-cholesterol metabolism as early as in adolescence. Our data also suggest possible associations between ANGPTL4 polymorphisms and body fat, but these findings require replication.
Vanessa Legry; Szilvia Bokor; Dominique Cottel; Laurent Beghin; Giovina Catasta; Eniko Nagy; Marcela Gonzalez-Gross; Andre Spinneker; Peter Stehle; D??nes Moln??r; Luis A Moreno; Philippe Amouyel; Jean Dallongeville; Aline Meirhaeghe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  94     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-04     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5070-7     Citation Subset:  AIM; IM    
Institut National de la Sant?? et de la Recherche M??dicale Unit?? 744, Institut Pasteur de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille Cedex, France.
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MeSH Terms
Adiposity / genetics*
Angiopoietins / genetics*
Cross-Sectional Studies
France / epidemiology
Gene Frequency
Genetic Variation
Lipid Metabolism / genetics*
Middle Aged
Motor Activity
Polymorphism, Genetic / genetics
Polymorphism, Single Nucleotide
Young Adult
Reg. No./Substance:
0/ANGPTL3 protein, human; 0/ANGPTL4 protein, human; 0/Angiopoietins

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