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Associations among chronic kidney disease, high total p-cresylsulfate and major adverse cardiac events.
MedLine Citation:
PMID:  22460182     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Cardiovascular disease is prevalent among patients with chronic kidney disease (CKD). Patients with CKD have elevated levels of p-cresylsulfate (PCS), which has been linked with cardiovascular mortality in this population. The aim of this study was to evaluate the clinical significance of CKD in coronary artery disease (CAD) patients and to investigate whether a significant correlation exists between CKD, total PCS and poor clinical outcomes in CAD patients. Methods: We assessed the occurrence of major adverse cardiac events (MACEs) among 340 consecutive CAD patients who enrolled in a disease management program after the patients were discharged from the hospital. CKD was defined as an estimated glomerular filtration rate (eGFR) of and lt;60 ml/min per 1.73 m2. Results: Kaplan-Meier analysis revealed that CKD and high total PCS levels ( and gt;1.66 mg/L) were significantly associated with the occurrence of MACE. A multivariate Cox hazard regression model revealed that the predictive independent risk factor for the occurrence of MACE was high total PCS level (relative risk = 1.387). We divided the patients with or without CKD and high or low total PCS levels into 4 groups according to their eGFR and total PCS levels, respectively. The hazard ratio for MACE in the group with both CKD and high total PCS level was 1.721, relative to the group without CKD that had low total PCS level (p=0.005). Conclusions: A high serum level of total PCS may be a predictor of elevated risk of MACE in CAD patients with low eGFR.
Authors:
Chao-Ping Wang; Li-Fen Lu; Teng-Hung Yu; Wei-Chin Hung; Cheng-An Chiu; Fu-Mei Chung; Chia-Chang Hsu; Yung-Chuan Lu; Yau-Jiunn Lee; Jer-Yiing Houng
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Journal of nephrology     Volume:  -     ISSN:  1724-6059     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
Affiliation:
Division of Cardiology, E-Da Hospital, I-Shou University, Kaohsiung - Taiwan; and Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung - Taiwan.
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