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Associations of Sedentary Time with Fat Distribution in a High-Risk Population.
MedLine Citation:
PMID:  25386715     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The effect of sedentary behaviour on regional fat deposition, independent of physical activity remains equivocal. We examined the cross-sectional associations between objectively measured sedentary time and markers of regional fat distribution (heart, liver, visceral, subcutaneous and total body fat) in a population at a high risk of type 2 diabetes mellitus (T2DM).
METHODS: Participants were recruited from primary care to two diabetes prevention programmes. Sedentary time (<25 counts per 15 seconds) was measured using Actigraph GT3X accelerometers. Heart, liver, visceral, subcutaneous and total body fat were quantified using magnetic resonance images (MRI). Fat volumes were calculated by multiplying the cross-sectional areas of the fat-containing pixels by the slice thickness. The liver fat percentage was measured using a representative region of interest created in the right lobe of the liver avoiding the main portal veins. Linear regression models examined the association of sedentary time with markers of regional fat deposition.
RESULTS: Sixty-six participants (age = 47.9±16.2 years; male = 50.0%) were included. Following adjustment for several covariates, including glycaemia, whole body fat and moderate-to-vigorous physical activity (MVPA), each 30 minutes of sedentary time was associated with 15.7cm higher heart fat (p=0.008), 1.2% higher liver fat (p=0.026) and 183.7cm higher visceral fat (p=0.039).
CONCLUSION: This study provides new evidence suggesting that objectively measured sedentary behaviour may have an independent association upon heart, liver and visceral fat in individuals at a high risk of T2DM.
Authors:
Joseph Henson; Charlotte L Edwardson; Bruno Morgan; Mark A Horsfield; Danielle H Bodicoat; Stuart Jh Biddle; Trish Gorely; Myra A Nimmo; Gerry P McCann; Kamlesh Khunti; Melanie J Davies; Thomas Yates
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-10
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-11     Completed Date:  -     Revised Date:  2014-11-12    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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