Document Detail

Associations of Proteinuria, Fluid Volume Imbalance, and Body Mass Index with Circadian Ambulatory Blood Pressure in Chronic Kidney Disease Patients.
MedLine Citation:
PMID:  23154648     Owner:  NLM     Status:  Publisher    
Background/Aims: Obesity and hypervolemic status are the main causes of hypertension in patients with chronic kidney disease (CKD). However, it is difficult to differentiate between them. We aimed to assess the associations of body mass index (BMI) and total body water (TBW) with ambulatory blood pressure (ABP). Methods: Body composition by bioelectrical impedance analysis (BIA) and 24-h ABP were measured in 40 patients with CKD. TBW was assessed using corrected TBW(BIA) adjusted for body surface area (cTBW(BIA)) and the TBW(BIA)/TBW(Watson) ratio obtained using an anthropometric formula (Watson). Results: Elevated ABP (average 24-h BP ≥ 135/85 mmHg) was noted in 23 patients, who were more likely to have a higher cTBW(BIA) and TBW(BIA)/TBW(Watson) ratio than patients without elevated BP. Patients with nocturnal non-dipping (<10% drop in BP during sleep) were more likely to have a higher TBW(BIA)/TBW(Watson) ratio. Proteinuria and the TBW(BIA)/TBW(Watson) ratio were significant independent factors for 24-h ABP. BMI had a positive correlation with the cTBW(BIA), TBW(BIA)/TBW(Watson) ratio and furosemide use. Conclusion: Hypertension is dependent on proteinuria and fluid volume imbalance. The TBW(BIA)/TBW(Watson) ratio can serve as an indicator of fluid volume-dependent hypertension. BMI is affected by TBW, in which case BMI can become less involved with 24-h ABP.
Yasushi Ohashi; Takatoshi Otani; Reibin Tai; Takayuki Okada; Kentarou Tanaka; Yoshihide Tanaka; Ken Sakai; Atsushi Aikawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  36     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  231-241     Citation Subset:  -    
Department of Nephrology, Toho University School of Medicine, Tokyo, Japan.
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