Document Detail


Associations of progesterone receptor polymorphisms with age at menarche and menstrual cycle length.
MedLine Citation:
PMID:  20814185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Age at menarche and menstrual cycle characteristics are indicators of endocrine function and may be risk factors for diseases such as reproductive cancers. The progesterone receptor gene (PGR) has been identified as a candidate gene for age at menarche and menstrual function.
METHODS: Women office workers ages 19-41 self-reported age at menarche and participated in a prospective study of menstrual function and fertility. First-morning urine was used as the DNA source. 444 women were genotyped for a functional variant in PGR, rs1042838 (Val660Leu), and 264 women were also genotyped for 29 other SNPs across the extended gene region.
RESULTS: Genetic variation across PGR was associated with age at menarche using a global score statistic (p = 0.03 among non-Hispanic whites). Women carrying two copies of the Val660Leu variant experienced menarche 1 year later than women carrying one or no copies of the variant (13.6 ± 0.5 vs. 12.6 ± 0.1; p = 0.03). The Val660Leu variant was also associated with decreased odds of short menstrual cycles (17-24 days) (OR, 95% CI: 0.54 [0.36, 0.80]; p = 0.002).
CONCLUSION: Genetic variation in PGR was associated with age at menarche and menstrual cycle length in this population. Further investigation of these associations in a replication dataset is warranted.
Authors:
K C Taylor; C M Small; M P Epstein; S L Sherman; W Tang; M M Wilson; M Bouzyk; M Marcus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-02
Journal Detail:
Title:  Hormone research in pædiatrics     Volume:  74     ISSN:  1663-2826     ISO Abbreviation:  Horm Res Paediatr     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-04-19     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  421-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Epidemiology, Emory University, Atlanta, Ga, USA. kirat @ email.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
DNA / chemistry,  genetics
Female
Genetic Variation
Genotype
Humans
Menarche / genetics*
Menstrual Cycle / genetics*
Polymorphism, Single Nucleotide
Receptors, Progesterone / genetics*
Regression Analysis
Sequence Analysis, DNA
Young Adult
Grant Support
ID/Acronym/Agency:
R01HD24618/HD/NICHD NIH HHS; R01HG03618/HG/NHGRI NIH HHS; R03HD55176/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Progesterone; 9007-49-2/DNA
Comments/Corrections

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