| Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study. | |
| | |
MedLine Citation:
|
PMID: 22344037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Accumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity. However, whether these maternal attributes are related to other cardiometabolic risk factors in adulthood has not been comprehensively studied. METHODS AND RESULTS: We used a birth cohort of 1400 young adults born in Jerusalem who had extensive archival data and clinical information at 32 years of age to prospectively examine the associations of mppBMI and GWG with adiposity and related cardiometabolic outcomes. Greater mppBMI, independently of GWG and confounders, was significantly associated with higher offspring BMI, waist circumference, systolic and diastolic blood pressures, insulin, and triglycerides and with lower high-density lipoprotein cholesterol. For example, the effect sizes were translated to nearly 5 kg/m(2) higher mean BMI, 8.4 cm higher waist circumference, 0.13 mmol/L (11.4 mg/dL) higher triglycerides, and 0.10 mmol/L (3.8 mg/dL) lower high-density lipoprotein cholesterol among offspring of mothers within the upper mppBMI quartile (mppBMI >26.4 kg/m(2)) compared with the lower quartile (mppBMI <21.0 kg/m(2)). GWG, independently of mppBMI, was positively associated with offspring adiposity; differences of 1.6 kg/m(2) in BMI and 2.4 cm in waist were observed when offspring of mothers in the upper (GWG >14 kg) and lower (GWG <9 kg) quartiles of GWG were compared. Further adjustment for offspring adiposity attenuated the observed associations to the null. CONCLUSIONS: Maternal size both before and during pregnancy is associated with cardiometabolic risk factors in young adult offspring. The associations appear to be driven mainly by offspring adiposity. Future studies that explore mechanisms underlying the intergenerational cycle of obesity are warranted to identify potentially novel targets for cardiometabolic risk-reduction interventions. |
| | |
Authors:
|
Hagit Hochner; Yechiel Friedlander; Ronit Calderon-Margalit; Vardiella Meiner; Yael Sagy; Meytal Avgil-Tsadok; Ayala Burger; Bella Savitsky; David S Siscovick; Orly Manor |
Related Documents
:
|
3359967 - Ontogeny of cytosolic androgen receptors in the brain of the fetal rhesus monkey. 17300967 - Sexual reproduction in the soybean sudden death syndrome pathogen fusarium tucumaniae. 19854517 - Early regulators in abortion and implications for a preeclampsia model. 19304417 - Characterization of seasonal reproduction patterns in female pichis zaedyus pichiy (xen... 3319557 - Physiologic assessment of fetal compromise: biomarkers of toxic exposure. 2239797 - Energy supplementation in the last trimester of pregnancy in east java, indonesia: effe... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-02-17 |
Journal Detail:
|
Title: Circulation Volume: 125 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-03-20 Completed Date: 2012-05-04 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 1381-9 Citation Subset: AIM; IM |
Affiliation:
|
Hebrew University-Hadassah, Braun School of Public Health, Jerusalem, Israel. hagit.hochner@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Adult Children* Birth Weight / physiology* Body Mass Index* Cardiovascular Diseases / blood, epidemiology*, physiopathology Cohort Studies Female Follow-Up Studies Humans Infant, Newborn Israel / epidemiology Male Metabolic Networks and Pathways / physiology Pregnancy Prenatal Care* / methods Prospective Studies Risk Factors Weight Gain / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 CA080197-07/CA/NCI NIH HHS; R01 HL088884-04/HL/NHLBI NIH HHS; R01CA80197/CA/NCI NIH HHS; R01HL088884/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
|
Circulation. 2012 Mar 20;125(11):1339-40
[PMID:
22344036
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gestational Weight Gain: Now and the Future.
Next Document: Evaluating The Bite of BARC.