| Associations of free fatty acids with insulin secretion and action among African-American and European-American girls and women. | |
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MedLine Citation:
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PMID: 19680231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethnic differences in insulin secretion and action between African Americans (AAs) and European Americans (EAs) may influence mobilization of free fatty acids (FFAs). We tested the hypotheses that FFA concentrations would be associated with measures of insulin secretion and action before and during a glucose challenge test. Subjects were 48 prepubertal girls, 60 premenopausal women, and 46 postmenopausal women. Fasting insulin (insulin(0)), the acute insulin response to glucose (AIR(g)), the insulin sensitivity index (S(I)), basal and nadir FFA (FFA(0), FFA(nadir)), and nadir time (TIME(nadir)) were determined during an intravenous glucose tolerance test (IVGTT). Stepwise multiple linear regression (MLR) analysis was conducted to identify associations of FFA(0), FFA(nadir), and TIME(nadir) with ethnicity, age group, insulin measures, indexes of body composition from dual-energy X-ray absorptiometry, and measures of fat distribution from computed tomography scan. In this population, insulin(0) and AIR(g) were higher among AAs vs. EAs, whereas S(I) was lower, independent of age group. MLR analyses indicated that FFA(0) was best predicted by lean tissue mass (LTM), leg fat mass, ethnicity (lower in AAs), S(I), and insulin(0). FFA(nadir) was best predicted by FFA(0), age group, and intra-abdominal adipose tissue (IAAT). TIME(nadir) was best predicted by leg fat mass, AIR(g), and S(I). In conclusion, indexes of insulin secretion and action were associated with FFA dynamics in healthy girls and women. Lower FFA(0) among AAs was independent of insulin(0) and S(I). Whether lower FFA(0) is associated with substrate oxidation or risk for obesity remains to be determined. |
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Authors:
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Laura Lee T Goree; Betty E Darnell; Robert A Oster; Marian A Brown; Barbara A Gower |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-13 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: 2011-06-20 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 247-53 Citation Subset: IM |
Affiliation:
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Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. llt@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adiposity / ethnology* Adolescent Adult African Americans* Age Factors Aged Aging / ethnology, metabolism Child European Continental Ancestry Group* Fatty Acids, Nonesterified / blood* Female Glucose Tolerance Test Humans Insulin / blood* Insulin Resistance / ethnology* Linear Models Middle Aged Obesity / ethnology*, metabolism, physiopathology Risk Assessment Risk Factors Time Factors Tomography, X-Ray Computed United States Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000032-440701/RR/NCRR NIH HHS; M01 RR000032-450701/RR/NCRR NIH HHS; M01 RR000032-460701/RR/NCRR NIH HHS; M01 RR000032-475085/RR/NCRR NIH HHS; M01-RR-00032/RR/NCRR NIH HHS; P30 DK056336-01/DK/NIDDK NIH HHS; P30 DK056336-02/DK/NIDDK NIH HHS; P30 DK056336-03/DK/NIDDK NIH HHS; P30 DK056336-069004/DK/NIDDK NIH HHS; P30 DK056336-079004/DK/NIDDK NIH HHS; P30 DK056336-089004/DK/NIDDK NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; P60 DK079626-01/DK/NIDDK NIH HHS; P60 DK079626-02/DK/NIDDK NIH HHS; P60-DK079626/DK/NIDDK NIH HHS; R01 DK058278-01/DK/NIDDK NIH HHS; R01 DK058278-02/DK/NIDDK NIH HHS; R01 DK058278-03/DK/NIDDK NIH HHS; R01 DK058278-03S1/DK/NIDDK NIH HHS; R01 DK058278-04/DK/NIDDK NIH HHS; R01 DK058278-04S1/DK/NIDDK NIH HHS; R01DK58278/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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