Document Detail

Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men.
MedLine Citation:
PMID:  20821938     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: D-dimer and von Willebrand factor (vWF) are associated with atherosclerosis. We recently reported that in a post-World War II birth cohort, Japanese men in Japan had lower levels of atherosclerosis than white men in the United States (U.S.). We examined whether the differences in D-dimer and vWF levels are associated with differences in atherosclerosis between the two populations.
METHODS AND RESULTS: Population-based samples of 99 Japanese and 100 white American men aged 40-49 years were examined for coronary artery calcification (CAC), carotid intima-media thickness (IMT), D-dimer, vWF, and other factors using a standardized protocol. When compared to white American men,Japanese had similar levels of D-dimer (0.22 +/- 0.28 vs. 0.19 +/- 0.24 microg/L, respectively, P = 0.39) but significantly higher levels of vWF (124.1 +/- 36.6 vs. 91.3 +/- 48.8%, respectively, P < 0.01). Japanese as compared to white American men had significantly lower prevalence of CAC (13.1 vs. 28.0%, P < 0.01, respectively) and significantly lower IMT (0.61 +/- 0.07 vs. 0.66 +/- 0.08 mm, P < 0.01, respectively). Japanese men had a significant positive association of D-dimer with the prevalence of CAC and a negative association of vWF with IMT, whereas white American men did not have any significant associations.
CONCLUSIONS: In men aged 40-49 years, Japanese as compared to white Americans had similar levels of D-dimer and higher levels of vWF although Japanese had a significantly lower prevalence of CAC and IMT. These haemostatic factors are unlikely to explain the difference in atherosclerosis in these populations.
Ryoko W Azuma; Takashi Kadowaki; Aiman El-Saed; Hirotsugu Ueshima; Kim Sutton-Tyrrell; Yasuyuki Nakamura; Daniel Edmundowicz; Yoshiki Ueno; Rhobert W Evans; Aya Kadota; Lewis H Kuller; Kiyoshi Murata; Tomoko Takamiya; Sayaka Kadowaki; J David Curb; Akira Sekikawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cardiologica     Volume:  65     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2010-11-02     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
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MeSH Terms
Atherosclerosis / blood*,  epidemiology,  ethnology*,  pathology
Chi-Square Distribution
Cross-Sectional Studies
Fibrin Fibrinogen Degradation Products / metabolism*
Japan / epidemiology
Linear Models
Middle Aged
Risk Factors
Tunica Intima / pathology
United States / epidemiology
von Willebrand Factor / metabolism*
Grant Support
R01 HL068200/HL/NHLBI NIH HHS; R01 HL068200-01A1/HL/NHLBI NIH HHS; R01 HL068200-02/HL/NHLBI NIH HHS; R01 HL068200-03/HL/NHLBI NIH HHS; R01 HL068200-04/HL/NHLBI NIH HHS; R01 HL68200/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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