| Associations between collagen synthesis and degradation and aortic function in arterial hypertension. | |
| | |
MedLine Citation:
|
PMID: 20134406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Studies have suggested that collagen accumulation in the aortic wall may contribute to the stiff aorta in arterial hypertension. However, data in human hypertension are limited. In this investigation, relations between markers of collagen metabolism and aortic function in patients with arterial hypertension were evaluated. METHODS: We studied 72 hypertensive patients (age 53 +/- 5 years) and 27 age- and gender-matched normotensive individuals. Elastic properties of the aorta were assessed by aortic pulse wave velocity (carotid-to-femoral pulse wave velocity (PWVc-f)). Free amino-terminal propeptides of precollagen type I (PINP, reflecting collagen I synthesis), serum telopeptides of collagen type I (CITP, an index of collagen I degradation), free amino-terminal propeptides on precollagen type III (PIIINP, reflecting collagen III metabolism), prometalloproteinase-1 (proMMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels were determined by commercially available immunoassays. RESULTS: Patients with arterial hypertension had greater PWVc-f (P = 0.01); and higher levels of PINP/CITP compared to control (P = 0.04). PWVc-f was significantly associated with PINP/CITP ratio (analysis of variance (ANOVA), P = 0.03). Hypertensive patients had significantly higher levels of proMMP-1/TIMP-1 (P = 0.04); PWVc-f was significantly associated with proMMP-1 (ANOVA, P = 0.03) and proMMP-1/TIMP-1 (ANOVA, P = 0.04). Associations between PWVc-f and proMMP-1 and between PWVc-f and PINP/CITP ratio remained significant after adjustment for PWVc-f confounders and antihypertensive treatment. CONCLUSIONS: Alterations in collagen turnover that favor collagen type I synthesis; as well as proMMP-1 expression are related to increased aortic stiffness in treated hypertensive individuals without left ventricular (LV) hypertrophy. |
| | |
Authors:
|
Dimitrios A Stakos; Dimitrios N Tziakas; George K Chalikias; Kostantina Mitrousi; Christina Tsigalou; Harisios Boudoulas |
Related Documents
:
|
7431176 - Pulmonary arterial lipid deposit in newborn infants receiving intravenous lipid infusion. 15838366 - Stride 1: effects of the selective et(a) receptor antagonist, sitaxsentan sodium, in a ... 17086016 - Arterial elasticity and erectile dysfunction in hypertensive men. 12900746 - Pulmonary hypertension: work in progress. 21422056 - Expanding current evar indications to include small abdominal aortic aneurysms: a glimp... 10147176 - Characterization of a polyepoxy compound fixed porcine heart valve bioprosthesis. |
Publication Detail:
|
Type: Journal Article Date: 2010-02-04 |
Journal Detail:
|
Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-20 Completed Date: 2010-07-22 Revised Date: 2011-06-30 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 488-94 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. dstakos@med.duth.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aorta
/
physiopathology* Case-Control Studies Collagen / metabolism* Collagen Type I / metabolism Elasticity / physiology Female Humans Hypertension / physiopathology* Male Matrix Metalloproteinase 1 / metabolism Middle Aged Peptide Fragments / metabolism Procollagen / metabolism Regional Blood Flow / physiology Tissue Inhibitor of Metalloproteinase-1 / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Collagen Type I; 0/Peptide Fragments; 0/Procollagen; 0/Tissue Inhibitor of Metalloproteinase-1; 0/procollagen Type I N-terminal peptide; 0/procollagen Type III-N-terminal peptide; 9007-34-5/Collagen; EC 3.4.24.7/Matrix Metalloproteinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysacch...
Next Document: A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Ch...