Document Detail

Associations Between Bilateral Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) and Anxiety in Parkinson's Disease Patients: A Controlled Study.
MedLine Citation:
PMID:  23037645     Owner:  NLM     Status:  In-Data-Review    
The authors explored the associations between subthalamic nucleus deep brain stimulation (STN-DBS) and anxiety in Parkinson's disease (PD) patients. Recent research suggests that anxiety may be one of the earliest manifestations of PD; however, the lack of a dopamine-medication control group is a major limitation of these studies. Authors paired a group of 31 bilateral STN-DBS PD patients (STN-DBS group) with 31 dopamine-medicated PD patients (Medication-control group) and used various psychological assessment scales for group evaluations. These were completed 1 month preoperatively, and 3 weeks, 5 weeks, 2 months, 4 months, 7 months, and 13 months postoperatively. As compared with the Medication group, the STN-DBS group improved in motor functioning and general status after 1 week Stimulator Power-On; State-Anxiety improved significantly at 1 week and 1 month after Stimulator Power-On, but was not significant at the subsequent time-points. Anxiety scores remained stable before 3rd-month Stimulator Power-On, but got worse after that time. In the STN-DBS group, S-AI was positively related to motor symptoms and life quality preoperatively and 4 months postoperatively, but, in the Medication group, this correlation existed throughout the study. PD-related anxiety decreased in STN-DBS patients because of the improvement in motor function for a short time; however, as the voltages and pulse-widths grew higher with time, the PD-related anxiety became worse.
Chongwang Chang; Nan Li; Yuyan Wu; Ning Geng; Shunnan Ge; Jing Wang; Xin Wang; Xuelian Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  24     ISSN:  1545-7222     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  316-25     Citation Subset:  IM    
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