Document Detail


Associations between arterial elasticity and markers of inflammation in healthy older women.
MedLine Citation:
PMID:  22987795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this investigation was to examine the associations between circulating markers of inflammation and arterial elasticity in healthy older women. Participants were 50 women older than 60 years of age, body mass index 27 ± 4, and physically untrained. Large artery elasticity, small artery elasticity, systemic vascular resistance, total vascular impedance, estimated cardiac output, and estimated cardiac index were determined using pulse contour analysis. Serum concentrations of tumor necrosis factor-α, C-reactive protein (CRP), and interleukin 6 were assessed. Results from Pearson's correlation revealed that tumor necrosis factor-α was inversely associated with large artery elasticity (-.426, p < .01) and estimated cardiac index (-.324, p < .05) and positively associated with systemic vascular resistance (.386, p < .01) and total vascular impedance (.416, p < .01). Additionally, C-reactive protein was inversely associated with large artery elasticity (-.308, p < .01). The overall implication was that tumor necrosis factor-α and C-reactive protein appear to be critical inflammatory cytokines associated with reductions in arterial elasticity in older women.
Authors:
Gordon Fisher; Gary R Hunter; Stephen P Glasser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-17
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  68     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-05-24     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteries / physiology*
Biological Markers / blood
Body Mass Index
C-Reactive Protein / analysis*
Cross-Sectional Studies
Elasticity / physiology*
Female
Heart Function Tests / methods
Hemorheology / physiology
Humans
Inflammation / blood*
Interleukin-6 / blood*
Middle Aged
Tumor Necrosis Factor-alpha / blood*
Vascular Resistance / physiology
Women's Health
Grant Support
ID/Acronym/Agency:
P30 DK056336/DK/NIDDK NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; R01AG027084-01/AG/NIA NIH HHS; T32 DK062710/DK/NIDDK NIH HHS; T32DK062710-07/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein
Comments/Corrections

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