Document Detail

Associations of ATGL gene polymorphisms with chicken growth and fat traits.
MedLine Citation:
PMID:  20453305     Owner:  NLM     Status:  MEDLINE    
Adipose triglyceride lipase (ATGL) catalyses the initial step in triglyceride hydrolysis, so the ATGL gene is a candidate for growth and fat traits in chickens. Nine reported single-nucleotide polymorphisms (SNPs) located in 3 exons of the chicken ATGL gene were chosen for genotyping an F2 population. Only 5 SNPs were confirmed for polymorphisms and used for association analyses. The results show that c.531G>A (p.E177Syn) was not associated with any growth and fat traits (P > 0.05), but c.782G>A (p.S261N) was associated with body weight (BW) on days 14, 21, 35, 63, 70, 77, cingulated fat width and abdominal fat pad weight (P < 0.05), and significantly associated with BW on days 42, 49, and 56 (P < 0.01). Significant associations of c.903C>T (p.F301Syn) with BW on days 49 and 77 days and crude protein content of breast muscle (P < 0.05), and c.1164G>A (p.K388Syn) with BW on day 7 (P < 0.05) were also detected. Additionally, c.1069T>C (p.L357Syn) was associated with breast muscle colour (P < 0.05), and significantly associated with crude fat (ether extract) content of breast muscle (P < 0.01). Thus the missense SNP of c.782G>A (p.S261N) was significantly associated with the largest number of chicken growth and fat traits in this study.
Q-H Nie; M-X Fang; L Xie; X Shen; J Liu; Z-P Luo; J-J Shi; X-Q Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied genetics     Volume:  51     ISSN:  1234-1983     ISO Abbreviation:  J. Appl. Genet.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9514582     Medline TA:  J Appl Genet     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
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MeSH Terms
Adipose Tissue / anatomy & histology*
Body Weight / genetics
Chickens / genetics*,  growth & development
Crosses, Genetic
Genetic Markers
Lipase / genetics*
Open Reading Frames
Polymorphism, Genetic*
Polymorphism, Single Nucleotide*
Reg. No./Substance:
0/Genetic Markers; EC

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