Document Detail

Association of a woman's own birth weight with subsequent risk for gestational diabetes.
MedLine Citation:
PMID:  12020334     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Several studies have reported links between reduced fetal growth and subsequent risk for type 2 diabetes among older adults, but the association between indices of fetal growth and gestational diabetes mellitus (GDM), a major complication of pregnancy and a strong predictor of type 2 diabetes, remains little explored.
OBJECTIVE: To test the hypothesis that a woman's own fetal growth is inversely related to her later risk for GDM.
DESIGN AND SETTING: Case-control study of linked hospital discharge and vital record data from the New York State Department of Health.
POPULATION: Healthy women who completed their first pregnancies in New York State between 1994 and 1998 and who were also born in New York State. Records from each woman's first pregnancy were linked to those from her own birth (1970-1985). Cases were 440 women with a record of GDM. Controls were 22 955 remaining women with no indication of GDM.
MAIN OUTCOME MEASURE: A woman's own birth weight, alone and adjusted for gestational age.
RESULTS: Birth weight showed a U-shaped relationship to a woman's risk of GDM in her first pregnancy, with the highest risks associated with low and high birth weights. Odds ratios (ORs) adjusted for gestational age were 2.16 (95% confidence interval [CI], 1.04-4.50) for birth weight of less than 2000 g and 1.53 (95% CI, 1.03-2.27) for a birth weight of 4000 g or more. Adjustment for potential confounding factors, particularly prepregnancy body mass index and maternal diabetes, increased the OR for low birth weight to 4.23 (95% CI, 1.55-11.51), but reduced the OR for high birth weight to 0.92 (95% CI, 0.54-1.57), leaving a strong inverse dose-response relationship between birth weight and risk of GDM (adjusted P for trend <.001).
CONCLUSIONS: In this large population-based study, a woman's own birth weight was strongly and inversely related to her risk of GDM, suggesting that early life factors may be important in the etiology of this disorder.
Kim E Innes; Tim E Byers; Julie A Marshall; Anna Barón; Miriam Orleans; Richard F Hamman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  287     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-05-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2534-41     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight*
Body Mass Index
Case-Control Studies
Diabetes, Gestational / epidemiology*,  etiology*
Embryonic and Fetal Development*
Gestational Age
Logistic Models
Grant Support
Erratum In:
JAMA 2002 Jun 26;287(24):3212

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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