Document Detail

Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies.
MedLine Citation:
PMID:  23054016     Owner:  NLM     Status:  Publisher    
Vitamin D receptor (VDR) BsmI gene polymorphism has been reported to be strongly associated with osteoporosis risk in some studies. However, the results from those studies are still conflicting. We performed a meta-analysis of studies relating the VDR BsmI gene polymorphism to the risk of osteoporosis. The search was performed in the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of October 1, 2011, and the eligible investigations were recruited for this meta-analysis. Forty-one investigations were identified for the meta-analysis of association between VDR BsmI gene polymorphism and osteoporosis risk. There lacked an association between VDR BsmI gene polymorphism and osteoporosis risk for overall populations, Caucasians and Asians (overall populations: B vs b: p = 0.65, BB vs (Bb + bb): p = 0.14, bb vs (BB + Bb): p = 0.86; Caucasians: B vs b: p = 0.65, BB vs (Bb + bb): p = 0.38, bb vs (BB + Bb): p = 0.83; Asians: B vs b: p = 0.87, BB vs (Bb + bb): p = 0.62, bb vs (BB + Bb): p = 0.66). In conclusion, VDR BsmI B/b gene polymorphism is not associated with the susceptibility of osteoporosis in overall populations, Caucasians, and Asians.
Gang Qin; Zhiyong Dong; Ping Zeng; Mingwei Liu; Xiaobo Liao
Related Documents :
10203016 - Susceptibility to ankylosing spondylitis is independent of the bw4 and bw6 epitopes of ...
23316436 - Comparison of the performance of two commercial genome-wide association study genotypin...
24584466 - Polymorphism in cytochrome p450 2d6, glutathione s-transferases pi 1 genes, and organoc...
24039736 - Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorec...
16396936 - Specific haplotypes of the calpain-5 gene are associated with polycystic ovary syndrome.
11533716 - Monogenic causes of x-linked mental retardation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Molecular biology reports     Volume:  -     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Osteoarthrosis, The First Affiliated Hospital Guangxi Traditional Chinese Medical University, No. 89-9, Dongge Road, Nanning, 530023, Guangxi, People's Republic of China,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 emb...
Next Document:  The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on ...