Document Detail

Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study.
MedLine Citation:
PMID:  19955400     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved.
OBJECTIVE: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress.
DESIGN: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and an oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y).
RESULTS: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively).
CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population.
Jian Shen; Chao-Qiang Lai; Josiemer Mattei; Jose M Ordovas; Katherine L Tucker
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-12-02
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  91     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-22     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  AIM; IM    
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111-1524, USA.
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MeSH Terms
C-Reactive Protein / metabolism
Cardiovascular Diseases / blood,  metabolism*,  prevention & control,  urine
Cross-Sectional Studies
Deoxyguanosine / analogs & derivatives,  urine
Hispanic Americans
Inflammation / metabolism*
Metabolic Syndrome X / metabolism*
Middle Aged
Oxidative Stress / physiology*
Pyridoxal Phosphate / blood
Statistics, Nonparametric
Vitamin B 6 / metabolism*
Grant Support
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 54-47-7/Pyridoxal Phosphate; 8059-24-3/Vitamin B 6; 9007-41-4/C-Reactive Protein; 961-07-9/Deoxyguanosine

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