| Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. | |
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MedLine Citation:
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PMID: 19955400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved. OBJECTIVE: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress. DESIGN: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and an oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y). RESULTS: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively). CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population. |
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Authors:
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Jian Shen; Chao-Qiang Lai; Josiemer Mattei; Jose M Ordovas; Katherine L Tucker |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-12-02 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-02-22 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 337-42 Citation Subset: AIM; IM |
Affiliation:
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Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111-1524, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Boston C-Reactive Protein / metabolism Cardiovascular Diseases / blood, metabolism*, prevention & control, urine Cross-Sectional Studies Deoxyguanosine / analogs & derivatives, urine Female Hispanic Americans Humans Inflammation / metabolism* Male Metabolic Syndrome X / metabolism* Middle Aged Oxidative Stress / physiology* Pyridoxal Phosphate / blood Statistics, Nonparametric Vitamin B 6 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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01AG023394-02/AG/NIA NIH HHS; HL54776/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/8-hydroxy-2'-deoxyguanosine; 54-47-7/Pyridoxal Phosphate; 8059-24-3/Vitamin B 6; 9007-41-4/C-Reactive Protein; 961-07-9/Deoxyguanosine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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