| Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy. | |
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MedLine Citation:
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PMID: 20801146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component. |
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Authors:
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Hille W van Dijk; Frank D Verbraak; Marilette Stehouwer; Pauline H B Kok; Mona K Garvin; Milan Sonka; J Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-27 |
Journal Detail:
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Title: Vision research Volume: 51 ISSN: 1878-5646 ISO Abbreviation: Vision Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-08-12 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: England |
Other Details:
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Languages: eng Pagination: 224-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Dept of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. h.w.vandijk@amc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus, Type 1 / physiopathology* Diabetic Retinopathy / physiopathology* Female Humans Macula Lutea / pathology Male Middle Aged Retinal Ganglion Cells / pathology* Tomography, Optical Coherence / methods Visual Acuity / physiology* Visual Fields / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY017066-01/EY/NEI NIH HHS; R01 EY017066-02/EY/NEI NIH HHS; R01 EY017066-03/EY/NEI NIH HHS; R01 EY017066-04/EY/NEI NIH HHS; R01-EY017066/EY/NEI NIH HHS |
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